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| http://dx.doi.org/10.17879/freeneuropathology-2024-5891 | DOI Listing |
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Infantile pilocytic astrocytoma with persisting external granular layer of the cerebellum: a potential diagnostic pitfall.
Free Neuropathol
January 2024
Department of Neuropathology, GHU Paris - Psychiatry and Neuroscience, Sainte-Anne Hospital, 75014 Paris, France.
Low-grade glioma of the temporal lobe and tumor-related epilepsy in children.
Childs Nerv Syst
October 2024
Department of Neurosurgery, The Royal Children's Hospital, Melbourne, Australia.
Article Synopsis
- Low-grade gliomas are the most common brain tumors in children and adolescents, often leading to uncontrolled seizures when located in the temporal lobe.
- A review of literature highlights various tumor types, surgical treatment options, and outcomes, indicating that complete resection of tumors is crucial for achieving favorable seizure outcomes.
- Management of these conditions should involve a multidisciplinary team focused on epilepsy surgery, as early and effective intervention significantly improves patient survival and reduces seizure-related issues.
Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.
Brain Pathol
September 2023
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Fusions involving CRAF (RAF1) are infrequent oncogenic drivers in pediatric low-grade gliomas, rarely identified in tumors bearing features of pilocytic astrocytoma, and involving a limited number of known fusion partners. We describe recurrent TRAK1::RAF1 fusions, previously unreported in brain tumors, in three pediatric patients with low-grade glial-glioneuronal tumors. We present the associated clinical, histopathologic and molecular features.
View Article and Find Full Text PDFA comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant-type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma.
Brain Pathol
September 2023
Department of Neuropathology, GHU Paris-Psychiatrie et Neurosciences, Sainte-Anne Hospital, Paris, France.
Article Synopsis
- Scientists discovered a new type of brain tumor called infant-type hemispheric glioma (IHG) that mostly affects babies.
- Unlike another brain tumor known as desmoplastic infantile ganglioglioma (DIG/DIA), IHG has different genetic changes, which makes it special.
- The researchers studied 30 tumors to find differences in how they look and their DNA, and found important characteristics that help distinguish between DIG/DIA and IHG.
Optic Neuropathy Revealing Severe Superficial Siderosis in the Setting of Long-standing Low-grade Intracranial Neoplasm.
Neuroophthalmology
August 2021
Ophthalmology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Two cases of optic neuropathy due to superficial siderosis (SS) are reported in two patients, aged 29 and 38 years, operated for intracranial neoplasms, the first one with a desmoplasic infantile ganglioglioma excised in 1991, and the other one with a pilocytic astrocytoma, operated on in 1997, 1998 and 2016. Both patients presented with progressive loss of visual acuity, as a result of bilateral optic nerve atrophy, as well as unsteadiness, ataxic gait and hearing loss. Magnetic resonance imaging (MRI) of the brain and spine, including gradient echo (GRE) T2-weighted acquisitions, revealed thin optic nerves and strong hypointensity with susceptibility artefacts corresponding to haemosiderin deposits within the meningeal layers of the spine, the infra- and supratentorial spaces of the brain and the peri-optic sheaths in both patients.
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