AI Article Synopsis

  • The study investigates how serum aquaporin 8 (AQP8) expression can be used to assess hydrolabyrinth severity and predict outcomes for patients with Meniere's disease.
  • A total of 105 patients with Meniere's disease and 102 healthy individuals were analyzed, revealing significantly higher AQP8 levels in patients, especially those with more severe hydrops.
  • Findings suggest that AQP8 mRNA levels could serve as a useful biomarker for predicting poor prognosis in these patients, with a notable predictive accuracy (AUC of 0.812).

Article Abstract

Objective: This study aims to explore the role of serum aquaporin 8 (AQP8) expression in evaluating the degree of hydrolabyrinth and predicting prognosis in patients with Meniere's disease.

Methods: One hundred and five patients diagnosed with Meniere's disease in our hospital were enrolled in the Meniere's disease group. Another 102 healthy subjects were enrolled as the control group. The expression of serum AQP8 mRNA was determined by the quantitative real-time PCR (qRT-PCR) method. Receiver operating characteristic (ROC) curve analysis was carried out to analyse the predictive value of serum AQP8 mRNA expression for poor prognosis in Meniere's disease patients. Multivariate logistic regression was used to analyse the influencing factors of poor prognosis in patients with Meniere's disease.

Results: The expression level of serum AQP8 mRNA in the Meniere's disease group was significantly higher than that in the control group (p < 0.05). In the severe hydrops group, serum AQP8 mRNA expression levels were higher than in the mild hydrops group and the no endolymphatic hydrops group. Additionally, the mild hydrops group had higher serum AQP8 mRNA levels than the no endolymphatic hydrops group (p < 0.05). The disease course, proportion of severe hydrops and serum AQP8 mRNA expression were all higher in the poor prognosis group compared to the good prognosis group (p < 0.05). The area under the curve (AUC) for serum AQP8 mRNA in predicting poor prognosis in Meniere's disease patients was 0.812 (95%CI: 0.702-0.922).

Conclusion: AQP8 mRNA is associated with the degree of hydrolabyrinth in patients with Meniere's disease and plays an important role in predicting prognosis.

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Source
http://dx.doi.org/10.1111/coa.14241DOI Listing

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