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Pregnancy zone protein, a potential research target in multiple diseases. | LitMetric
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Pregnancy zone protein, a potential research target in multiple diseases.

You Wu Zhicong Zhao Xia Deng Jue Jia Guoyue Yuan

Gene

Department of Endocrinology and Metabolism, The Affiliated Hospital of Jiangsu University, Institute of Endocrine and Metabolic Diseases, Jiangsu University, Zhenjiang, Jiangsu 212001, China. Electronic address:

Published: January 2025

AI Article Synopsis

  • - Pregnancy zone protein (PZP) is an immunosuppressant from the α-macroglobulin family, secreted by the liver and increased in pregnant women; it shares 71% similarity with α-2-macroglobulin (A2M), but low PZP levels don't raise A2M during pregnancy.
  • - PZP interacts with several biological factors, including low-density lipoprotein receptor-associated protein and transforming growth factor-β, and is linked to conditions like Alzheimer's disease, rheumatoid arthritis, and metabolic disorders.
  • - The review examines PZP's role in the development and progression of various diseases, including different types of cancer, highlighting its importance in understanding pathophysiology.

Article Abstract

Pregnancy zone protein (PZP) is an antiprotease-resistant immunosuppressant belonging to the α-macroglobulin (αM) protein family. PZP is secreted by the liver and was found to be upregulated in plasma during pregnancy. α-2-macroglobulin (Α2M) shares 71 % serial homology with PZP, but low PZP levels do not lead to increased A2M levels in pregnancy. PZP can interact with several factors such as low-density lipoprotein receptor-associated protein (LRP), transforming growth factor-β (TGF-β), 78 kDa glucose-regulated protein (GRP78), and glycoside A (GdA). PZP is involved in the development of glycolipid metabolism disorders, bronchiectasis, Alzheimer's disease (AD), rheumatoid arthritis (RA), myocardial infarction (MI) and inflammatory bowel disease (IBD). PZP is also associated with the progression of tumorigenesis such as breast cancer (BC), homologyepatocellular carcinoma (HCC), lung adenocarcinoma (LAC), and colorectal cancer (CRC). Therefore, this review analyzes the role of PZP in pathophysiology of various diseases.

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 Source
http://dx.doi.org/10.1016/j.gene.2024.149013DOI Listing

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