AI Article Synopsis
- Long-term stress may influence eating habits and contribute to obesity by affecting hormones that regulate appetite and metabolism.
- A study with 65 obese patients examined the relationship between stress (both biological and psychological) and various appetite-regulating hormones.
- The findings suggest that higher levels of hair cortisone are positively linked to increased cholecystokinin, indicating a connection between persistent biological stress and hormonal changes related to appetite.
Article Abstract
Introduction: Stress predicts unhealthy eating, obesity, and metabolic deterioration, likely mediated by altered levels of appetite-regulating hormones. Yet, evidence regarding the association between long-term stress and levels of appetite-regulating hormones in humans is lacking.
Methods: We included 65 patients with obesity (44 women) to investigate the cross-sectional association of long-term biological stress (scalp hair cortisol and cortisone) and long-term psychological stress (Perceived Stress Scale) with overnight-fasted serum levels of the hormonal appetite regulators leptin, adiponectin, insulin, pancreatic polypeptide, gastric-inhibitory peptide, peptide tyrosine-tyrosine, cholecystokinin and agouti-related protein, adjusted for age, sex, and body mass index.
Results: Hair cortisone and, in trend, hair cortisol were positively associated with cholecystokinin (p = 0.003 and p = 0.058, respectively). No other associations between stress measures and hormonal appetite regulators were observed.
Conclusion: Long-term biological stress, measured using scalp hair glucocorticoid levels, is associated with elevated levels of circulating cholecystokinin. More research is needed to pinpoint potential effects on appetite.
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| http://dx.doi.org/10.1159/000542079 | DOI Listing |
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