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Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention.
Exp Gerontol
January 2025
Shanghai anti-doping Laboratory, Shanghai University of Sport, Shanghai 200438, China; Department of Rheumatology and Immunology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and neurokines, act both locally and systemically to exert protective effects against the detrimental aspects of aging.
View Article and Find Full Text PDFE3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases.
Pharmacol Res
January 2025
State Key Laboratory of Frigid Zone Cardiovascular Disease, Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning, China. Electronic address:
Numerous studies conducted in recent years indicate that mammalian E3 ubiquitin ligases serve as key regulators in the maintenance of cellular homeostasis by targeting the ubiquitination of substrate proteins and activating downstream signaling pathways. SYVN1, an E3 ubiquitin ligase, is characterized by its significant functions in regulating various biological processes, including molecular mechanisms related to gene expression, signaling pathways, and cell death, among others. Consequently, SYVN1 plays a crucial role in both normal human physiology and the pathogenesis of various diseases, such as oncogenesis, cardiovascular disorders, immune regulation, skeletal anomalies, and neurological diseases.
View Article and Find Full Text PDFCan microbiota gut-brain axis reverse neurodegenerative disorders in human?
Ageing Res Rev
January 2025
Medical Science and Technology Innovation Center, Shandong Key Laboratory of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, Shandong 250117, P R China; School of Medicine and Allied Health Sciences, University of The Gambia; Department of Medical Microbiology, Central South University Changsha, Hunan Provinces, China. Electronic address:
The trillions of microbial populations residing in the gut have recently shown that they can be used as a remedy for various diseases. The gut microbiota-brain-axis interface is one unique pathway that the microbiota demonstrates its medicinal value. This medicinal value is further seen when there is a decline in gut microbial diversity (dysbiosis).
View Article and Find Full Text PDFSoil moisture drought and diverse impacts on vegetation across the Tibetan Plateau in recent three decades.
Sci Total Environ
January 2025
Key Laboratory of Lake and Watershed Science for Water Security, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, China. Electronic address:
Climate warming is presumed to cause drought on the Tibetan Plateau (TP), posing severe threats to local vegetation and ecosystems. Currently, soil moisture (SM) drought and its effects on vegetation growth have been rarely reported, due to lacking observations and data uncertainties. Here we used ERA5-Land, ESA CCI, and GLDAS Noah SM to investigate the spatiotemporal patterns of summertime (May-September) SM drought and its impacts on vegetation over 1995-2018.
View Article and Find Full Text PDFDynamic classification and attention mechanism-based bidirectional long short-term memory network for daily runoff prediction in Aksu River basin, Northwest China.
J Environ Manage
January 2025
College of Hydrology and Water Resources, Hohai University, Nanjing 210098, China.
Inland river runoff variability is pivotal for maintaining regional ecological stability. Daily flow forecasting in arid regions is crucial in understanding water body ecological processes and promoting healthy river ecology. Precise daily runoff forecasting serves as a cornerstone for ecological evaluation, management, and decision-making.
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