Purpose: The determinants of aerobic capacity are oxygen delivery by the cardiopulmonary system and oxygen extraction by the skeletal muscles. However, the impact of the oxygen extraction capacity of the skeletal muscle is unclear. This study aimed to examine the associations between aerobic capacity; muscle strength, endurance, mass, and quality; and oxygen extraction capacity.
Methods: Twenty-seven healthy young men (mean age, 20.7 ± 0.8 years; body mass index, 21.6 ± 3.2 kg m-2) were recruited. The following parameters were determined: peak work rate (WR) and oxygen uptake (V˙O2) corrected for body mass using the cardiopulmonary exercise testing; muscle strength and endurance using isokinetic muscle testing; muscle mass using bioelectrical impedance; muscle quality (muscle echo intensity) using an ultrasound imaging device, and muscle oxygen extraction rate (MOER) using near-infrared spectroscopy. Multiple regression analysis was performed using WR/kg peak and V˙O2/kg peak as dependent variables and each assessment index as an independent variable.
Results: Multiple regression analysis with WR/kg peak as the dependent variable resulted in the adoption of SMI (β = -0.41, P = 0.036), muscle echo intensity (β = -0.45, P = 0.012) and ΔMOER (β = 0.73, P < 0.001) as significantly associated factors. Multiple regression analysis with V˙O2/kg peak as the dependent variable resulted in ΔMOER (β = 0.65, P = 0.001) being adopted as a significantly associated factor.
Conclusion: These findings suggest that muscle oxygen extraction rate is associated with aerobic capacity. MOER is a useful indicator because it is not affected by body mass.
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http://dx.doi.org/10.1556/2060.2024.00424 | DOI Listing |
Alzheimers Dement
December 2024
Federal University of Technology, Akure, Ondo, Nigeria.
Background: In recent decades, epidemiological and experimental studies have looked into the role of pesticides, particularly the herbicide paraquat, in the development of Parkinson's disease. Horseradish tree (Moringa oleifera) is an ethnobotanical plant with lots of therapeutic potential, but there is a dearth of information on the bioactive properties of the seed alkaloid extracts.
Method: This study examined the modulatory effects of various concentrations of an alkaloid extract from the seeds of Horseradish Tree (Moringa oleifera) on the survival rate of flies exposed to paraquat, as well as certain biochemical and molecular markers related to Parkinson's disease in the heads of the flies.
Background: Reliable treatment approaches for addressing early cognitive impairment and Alzheimer's disease (AD) are currently lacking. Given the multifactorial nature of AD, therapeutic strategies need to focus on disease-specific biochemical pathways. Given the significance of metabolic pathways in cognitive impairment, it is essential to investigate alternative disease modifiers capable of targeting multiple metabolic pathways, such as phytochemicals.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Gachon University, Seongnam, Gyeonggido, Korea, Republic of (South).
Background: Anethum graveolans commonly known as Dill is an herb from celery family displaying anti-oxidant benefits. The present study focused on the potential of Anethum graveolans as a multifunctional curative remedy for AD treatment.
Method: Hexane (H) and ethyl acetate (EA) extracts of Dill were prepared and subjected to GC-MS for identification of important bioactive components.
Curr Pharm Des
January 2025
Department of Pharmacy, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.
Background: The metal oxide nanoparticles possess unique properties such as biological compatibility, superior reactivity, and capacity to develop reactive oxygen species, due to this they have drawn significant interest in cancer treatment. The various MONPs such as cerium oxide, Copper oxide, Iron oxide, Titanium dioxide, and Zinc oxide have been investigated for several types of cancers including brain, breast, cervical, colon, leukemia, liver, lung, melanoma, ovarian, and prostate cancers. However, traditional physiochemical synthetic methods for MONPs commonly include toxic materials, a major concern that raises questions regarding their biocompatibility and safety.
View Article and Find Full Text PDFCurr Pharm Biotechnol
January 2025
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China.
Introduction: Iron oxide nanozyme was synthesized from the fruit peel extract of pomegranate, which served as a reducing agent during the green synthesis. The scavenging of reactive oxygen species is often accompanied by immunomodulation following antiproliferative effects due to the crosstalk between the proteins involved in the inter-related signaling pathways.
Method: In the current study, the green synthesized nanozyme was studied for its ability to induce apoptosis in breast cancer cell lines.
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