Presented here is a sulfoximine-directed Ru(II)-catalyzed asymmetric intramolecular double C(sp)-H hydroarylation of olefins. This process provides a diastereoselective and enantiospecific synthetic route to highly substituted tetrahydrobenzodifurans. Notably, the reaction accommodates labile functional groups and is scalable to gram quantities.
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| http://dx.doi.org/10.1021/acs.orglett.4c03524 | DOI Listing |
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