AI Article Synopsis
Article Abstract
Antimicrobial resistance remains an enduring global health issue, manifested when microorganisms, such as bacteria, lack responsiveness to antimicrobial treatments. Photodynamic inactivation (PDI) of microorganisms arises as a noninvasive, nontoxic, and repeatable alternative for the inactivation of a broad range of pathogens. So, this study reports the synthesis, structural characterization, and photophysical properties of a new tetra-β-substituted pyridinium-pyrazolyl zinc(II) phthalocyanine (ZnPc ) that was compared with two previously described pyridinium-pyrazolyl ZnPcs and . The PDI efficacy of these three ZnPcs (-) against a drug-resistant Gram-positive bacterium (as ) and a Gram-negative bacterium (as ) is also reported. The PDI efficacy toward these bacteria was examined with ZnPcs - in the 5.0-10.0 μM range using a white light source with an irradiance of 150 mW/cm. All ZnPcs displayed a significant PDI activity against , with reductions superior to 3 Log CFU/mL. Increasing the treatment time, the was inactivated until the detection limit of the method (>6.3 Log CFU/mL) using the quaternized ZnPcs - (10.0 μM, 120 min) being the inactivation time was reduced when added the KI for ZnPcs and . These findings demonstrate the effective PDI performance of pyridinium-pyrazolyl group-bearing PSs, indicating their potential use as a versatile antimicrobial agent for managing infections induced by Gram-negative and Gram-positive bacteria.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsabm.4c01368 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antimicrobial activity of octyl gallate nanoemulsion combined with photodynamic technology and its effect on food preservation.
Int J Food Microbiol
December 2024
Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:
Photodynamic inactivation, as a safe and effective antimicrobial technology that does not damage the organoleptic properties of the food itself, decreases the use of preservatives and is gradually gaining attention in the food industry. This study selected octyl gallate (OG) as an antimicrobial photosensitizer with eucalyptus oil as the oil phase and prepared it as an octyl gallate nanoemulsion (OG-NE) to ensure the delivery of the photosensitizer. Escherichia coli and Staphylococcus aureus inactivation with the OG-NE combined with photodynamic technology, as well as the effect on the quality of food products, was investigated.
View Article and Find Full Text PDFNon-Thermal Treatment Mediated by Curcumin for Enhancing Food Product Quality.
Foods
December 2024
Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China.
Increasing antibiotic resistance is one of the world's greatest health problems, and biocide use in food disinfection, alongside other application fields, could increase antibiotic resistance. Effective and eco-friendly food decontamination treatment with minimal chemical intervention in food production is urgently needed. Synergistic antimicrobial interaction of photoactive compounds and blue-light-emitting diodes have recently been proven effective in agricultural and environmental applications.
View Article and Find Full Text PDFEnhancement of 5-Aminolevulinic Acid-Mediated Photodynamic Inactivation of Using Phosphoric and Bisaminophosphinic Acids as Permeabilizing Agents.
ACS Omega
December 2024
Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.
The purpose of this work was to examine the effect of phosphoric and bisaminophosphinic acids on the effectiveness of photoinactivation of with 5-aminolevulinic acid (5-ALA) as a precursor of protoporphyrin IX. Two diode lasers λ = 404 nm (radiation intensity 26 mW cm) and λ = 630 nm (radiation intensity 55 mW cm) were used as sources of light. The most effective agent was ()-(-)-1,1'-binaphthyl-2,2'-diylhydrogen phosphate, and a significant improvement in bactericidal effect of 5-ALA-aPDI was achieved by pretreating with this compound at nontoxic concentrations of 0.
View Article and Find Full Text PDFPhotonic hydrogels combining the slow photon effect and NO gas therapy for synergetic enhanced photodynamic antibacterial therapy.
J Colloid Interface Sci
December 2024
Key Lab of Material Chemistry for Energy Conversion and Storage of Ministry of Education, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China. Electronic address:
Photodynamic therapy (PDT) offers potential for combating bacterial infections through the generation of reactive oxygen species (ROS). However, the antibacterial efficiency of PDT is largely impeded by the limited photon absorption of photosensitizers and the short diffusion length and lifespan of ROS. Herein, we present a light-harvesting platform based on l-arginine-modified photonic hydrogels loaded with new indocyanine green (PG@Arg/IR820) for synergizing the slow photon effect with NO gas therapy to enhance PDT antibacterial efficiency.
View Article and Find Full Text PDFNatural borneol improves cellular uptake of curcumin to enhance its photodynamic bactericidal activity against Escherichia coli ATCC 8739.
Food Microbiol
April 2025
School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China; China-Singapore International Joint Research Institute, Guangzhou, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China. Electronic address:
Photodynamic inactivation (PDI), a non-thermal sterilization method, has attracted considerable attention due to its broad-spectrum antimicrobial activity, environmental friendliness and cost-effectiveness. Curcumin (Cur), a food-grade photosensitizer, exhibits photodynamic antimicrobial activity based primarily on its efficiency in intracellular accumulation. However, Cur's low water solubility and the barriers presented by the outer membrane of Gram-negative bacteria challenge its ability to penetrate the cytoplasm.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!