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Clinical Practice Recommendations on Kidney Management in Methylmalonic Acidemia: an Expert Consensus Statement From ERKNet and MetabERN.
Kidney Int Rep
December 2024
Division of Metabolic Diseases and Hepatology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Methylmalonic acidemias (MMAs) are rare inherited metabolic diseases with multiorgan involvement. Chronic kidney disease (CKD) is a common complication, leading to kidney failure, dialysis, and kidney transplantation (KT). The objective of these guidelines was to develop clinical practice recommendations focusing on specific aspects of the kidney management of this disease.
View Article and Find Full Text PDFEfficacy and Safety of Tenofovir Amibufenamide and Tenofovir Alafenamide for First-Time HBV-Related Decompensated Cirrhosis.
J Viral Hepat
October 2024
Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Clinical studies of tenofovir amibufenamide (TMF) and tenofovir alafenamide (TAF) treatment in patients with HBV-related decompensated cirrhosis (HBV-DC) are limited. This study evaluated the efficacy and safety of TMF versus TAF in naive-treated patients with first-time HBV-DC. Based on the antiviral drug used, patients were categorised into the TMF group and the TAF group.
View Article and Find Full Text PDFCystatin C and the difference between cystatin C and serum creatinine: Improved metrics to predict waitlist mortality among patients with decompensated cirrhosis.
Liver Transpl
January 2025
Department of Medicine, University of California-San Francisco, San Francisco, California, USA.
Article Synopsis
- Among patients with decompensated cirrhosis, Cystatin C (cysC) is a more accurate measure of kidney function related to waitlist mortality compared to serum creatinine (sCr), which is influenced by factors like sex and frailty.
- The study measured levels of cysC in 525 patients, defining the cysCsCr difference (cysCsCr diff) and analyzing its association with patient demographics, frailty, and mortality outcomes.
- Results showed that higher cysCsCr diff correlated with increased mortality risk, with each 1-point increase associated with a 1.72 times higher hazard of death on the waitlist, highlighting cysC as a valuable tool for assessing waitlist mortality
Soluble Suppression of Tumorigenicity 2 (sST2) in Patients with Predominantly Decompensated Right Heart Failure-A Prospective Observational Study.
J Clin Med
November 2023
Department of Cardiology, Heart Center Brandenburg Bernau & Faculty of Health Sciences (FGW) Brandenburg, Brandenburg Medical School (MHB) Theodor Fontane, Ladeburger Straße 17, 16321 Bernau bei Berlin, Germany.
Right heart failure is a major challenge in clinical practice. Soluble Suppression of Tumorigenicity-2 (sST2), a member of the interleukin-1-receptor family, may have clinical prognostic value. The aim of this study was to analyze whether sST2 correlates with signs of acute right heart decompensation.
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