Objective: An old disease called the Marburg virus infection has just recently started to appear in some African nations in recent years. The disease is currently being scrutinized for its potential to become a new global public health issue.
Methods: The authors of this work employed a mathematical modeling technique to determine the final seroprevalence rate.
Results: The seroprevalence rate can be estimated based on the results of the current investigation. This incidence may indicate that the endemic nation has an asymptomatic Marburg virus infection.
Conclusion: This may also point to the significance of a possible asymptomatic Marburg virus sickness, which may be the cause of the disease's broad transmission. In light of the resurfacing Marburg virus disease concern, it is important to recognize this problem.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487311 | PMC |
http://dx.doi.org/10.14744/nci.2023.47048 | DOI Listing |
Lancet
January 2025
Africa Centres for Disease Control and Prevention, Addis Ababa 1000, Ethiopia.
J Biol Chem
January 2025
Institute of Virology, Philipps University Marburg, Marburg, Germany. Electronic address:
Orthoflaviviruses are emerging arthropod-borne pathogens whose replication cycle is tightly linked to host lipid metabolism. Previous lipidomic studies demonstrated that infection with the closely related hepatitis C virus (HCV) changes the fatty acid (FA) profile of several lipid classes. Lipids in HCV-infected cells had more very long-chain and desaturated FAs and viral replication relied on functional FA elongation and desaturation.
View Article and Find Full Text PDFMar Drugs
January 2025
Nebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Filoviruses, mainly consisting of the two genera of and , are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates. However, we still do not have effective medicines for treating these diseases. To search for effective drugs, we have identified three marine indole alkaloids that exhibit potent activities against filovirus infection.
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