AI Article Synopsis
- - The study investigates the relationship between CD44 and CD63 protein expressions and various clinicopathological features in breast cancer, including tumor-infiltrating lymphocytes, specific genetic mutations, and patient survival rates.
- - Findings from 101 breast cancer samples reveal that high CD44 expression is linked to younger age, a triple-negative cancer type, and shorter survival, while high CD63 density correlates with estrogen receptor positivity and lower tumor-infiltrating lymphocyte levels.
- - The results suggest that CD44 is associated with more aggressive cancer characteristics, while lower CD63 density is observed in tumors with aggressive traits.
Article Abstract
Background: CD44 is a cell-surface transmembrane glycoprotein that participates in the regulation of many cellular processes, including cell division, adhesion, migration and stem-like characteristics. CD63 is involved in the exocytosis process.
Objective: To evaluate the relationship between CD44 and CD63 expression and clinicopathological features, including tumor-infiltrating lymphocytes (TILs), phosphoinositide 3-kinase (PIK3CA) mutation and survival.
Methodology: CD44 and CD63 were stained in samples from 101 breast cancer cases from Peruvian women.
Results: Median age was 52 years, most were most were grade-3 (68%), estrogen receptor (ER)+ (64%) and stage II-III (92%). Median ki67 was 30%, median stromal TIL was 30% and mutation was found in 49%. Longer survival was associated with earlier stages ( = 0.016), lower ki67 ( = 0.023), ER+ ( = 0.034), luminal phenotype ( = 0.029) and recurrence ( < 0.001). CD44 was classified as high cell density staining in 57% and high intensity in 55%. High CD44 density was associated with younger age ( = 0.043), triple-negative phenotype ( = 0.035) and shorter survival ( = 0.005). High CD44 expression was associated with short survival ( = 0.005). High CD63 cell density was found in 56% of cases and was associated with ER-positive ( = 0.045), low TIL levels ( = 0.007), Luminal-A ( = 0.015) and low CD44 intensity ( = 0.032).
Conclusion: CD44 expression was associated with aggressive features and low CD63 density staining.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489100 | PMC |
| http://dx.doi.org/10.3332/ecancer.2024.1779 | DOI Listing |
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Article Synopsis
- - The study investigates the relationship between CD44 and CD63 protein expressions and various clinicopathological features in breast cancer, including tumor-infiltrating lymphocytes, specific genetic mutations, and patient survival rates.
- - Findings from 101 breast cancer samples reveal that high CD44 expression is linked to younger age, a triple-negative cancer type, and shorter survival, while high CD63 density correlates with estrogen receptor positivity and lower tumor-infiltrating lymphocyte levels.
- - The results suggest that CD44 is associated with more aggressive cancer characteristics, while lower CD63 density is observed in tumors with aggressive traits.
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