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The Disseminated Gonococcal Disease (DGI) presents with varying signs and symptoms such as arthralgias and skin lesions to less commonly tenosynovitis posing a diagnostic challenge. In this case, a 64-year-old male presented to the emergency department with a 2-day history of flu-like symptoms, burning with urination, left ankle pain, erythema, and swelling. He met Systemic Inflammatory Response Syndrome (SIRS) criteria and was treated for presumed viral syndrome with supportive care. Blood cultures later grew . He was called back to the hospital and treated with IV ceftriaxone and oral doxycycline. Further questioning following his treatment revealed a social history significant for recent unprotected receptive oral intercourse with a male partner. This case highlights the importance of early risk stratification and a higher index of suspicion in keeping DGI in the differential diagnosis of tenosynovitis with fever.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488526 | PMC |
http://dx.doi.org/10.7759/cureus.69654 | DOI Listing |
Lancet Rheumatol
December 2024
Service de Rhumatologie, Hôpital Bichat-Claude Bernard, AP-HP, Paris, France; Center for Research in Epidemiology and Statistics, INSERM UMR 1153, Université Paris Cité, Paris, France. Electronic address:
Sex Transm Dis
October 2024
Sexually Transmitted Diseases (STD) Control Branch, Division of Communicable Disease Control (DCDC), Center for Infectious Diseases (CID), California Department of Public Health (CDPH), Richmond, California, USA.
Gonorrhea is a sexually transmitted infection. Manifestations include asymptomatic infection and disseminated, life-threatening disease. We present two cases of mitral valve gonococcal endocarditis and discuss epidemiologic trends in disseminated gonococcal infection, acknowledging antimicrobial resistance, genetic variability in gonococcal strains, and contextual factors related to the COVID-19 pandemic and STI control.
View Article and Find Full Text PDFAntimicrob Agents Chemother
December 2024
Department of Microbiology and Immunology, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Antimicrobial resistance in (Ng) has severely reduced treatment options, including azithromycin (AZM), which had previously been recommended as dual therapy with ceftriaxone. This study characterizes the emergence of high-level resistance to AZM (HLR-AZM) Ng in Baltimore, Maryland, USA, and describes the global evolution of HLR-AZM Ng. Whole genome sequencing (WGS) of 30 Ng isolates with and without HLR-AZM from Baltimore was used to identify clonality and resistance determinants.
View Article and Find Full Text PDFSex Transm Infect
October 2024
Department of Clinical Sciences, Belgian National Reference Centre for STIs, Institute of Tropical Medicine, Antwerpen, Belgium.
Cureus
September 2024
Department of Family Medicine, Creighton University School of Medicine, Phoenix, USA.
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