AI Article Synopsis
- Metabolites from microbial metabolism play a key role in health and diseases, particularly in conditions like metabolic dysfunction-associated steatotic liver disease (MASLD).
- Recent research highlights a connection between MASLD and an increased risk of chronic kidney disease (CKD), with changes in microbiota and metabolite profiles being significant factors.
- The review examines specific metabolites, including bile acids, fructose, vitamin D, and shifts in microbiota composition, that could explain the relationship between MASLD and CKD.
Article Abstract
Metabolites produced as intermediaries or end-products of microbial metabolism provide crucial signals for health and diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD). These metabolites include products of the bacterial metabolism of dietary substrates, modification of host molecules [such as bile acids (BAs), trimethylamine-N-oxide, and short-chain fatty acids], or products directly derived from bacteria. Recent studies have provided new insights into the association between MASLD and the risk of developing chronic kidney disease (CKD). Furthermore, alterations in microbiota composition and metabolite profiles, notably altered BAs, have been described in studies investigating the association between MASLD and the risk of CKD. This narrative review discusses alterations of specific classes of metabolites, BAs, fructose, vitamin D, and microbiota composition that may be implicated in the link between MASLD and CKD.
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| http://dx.doi.org/10.3350/cmh.2024.0782 | DOI Listing |
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