AI Article Synopsis
- * Their structures were determined through advanced spectroscopic methods, with absolute configurations established using specific rotations and electronic circular dichroism (ECD).
- * Several of the known compounds exhibited antibacterial and antifungal activity, with specific minimum inhibitory concentrations (MIC) indicating their effectiveness against methicillin-resistant bacteria and certain fungi.
Article Abstract
Three new isochroman derivatives, penicitrisochromans A-C (-), together with 25 known polyketides were isolated from the marine-derived fungus PSU-MF100. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of and were established by comparison of specific rotations and electronic circular dichroism (ECD) data with those of the known co-metabolite whereas those of were assigned based on the ECD calculation and biosynthetic consideration. Among the isolated polyketides, three known anthraquinone derivatives, -hydroxyemodin, penicillanthranin A and emodin, displayed moderate to strong antibacterial activity against methicillin-resistant with MIC values of 32, 16 and 4 g/mL, respectively. For antifungal activity, two known benzopyranones, coniochaetones A and C, exhibited moderate antifungal activity against NCPF3153 and ATCC90112 with the respective MIC values of 16 and 64 g/mL.
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| http://dx.doi.org/10.1080/14786419.2024.2416515 | DOI Listing |
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