AI Article Synopsis
- The study examines how porous additively manufactured polylactide (PLA) scaffolds, designed with triply periodic minimal surfaces (TPMS), behave under stress and where they are likely to fail.
- It focuses on the strain-amplification factor and identifies the most critical failure points based on numerical simulations and comparisons with a crack-growth algorithm using the extended finite element method (XFEM).
- The research also evaluates how the morphology of the scaffolds affects their performance during different loading conditions, offering insights into fracture behaviors and risk areas for crack initiation in AM-PLA scaffolds.
Article Abstract
In this paper, the mechanical behaviour and failure of porous additively manufactured (AM) polylactide (PLA) scaffolds based on the triply periodic minimal surfaces (TPMS) is investigated using numerical calculations of their unit cells and representative volumes. The strain-amplification factor is chosen as the main parameter, and the most critical locations for failure of different types of scaffold structures are evaluated. The results obtained are presented in comparison with a multiple-crack-growth algorithm using the extended finite element method (XFEM), underpinned by the experimentally obtained fracture properties of PLA. The effect of morphology of TPMS structures on the pre-critical, critical and post-critical behaviours of scaffolds under monotonic loading regimes is assessed. The results provide an understanding of the fracture behaviour and main risk points for crack initiation in structures of AM-PLA scaffolds based on typical commonly used types of TPMS, as well as the influence of structure type and external load on this behaviour.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.medengphy.2024.104235 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characterisation and modelling of continuous electrospun poly(ɛ- caprolactone) filaments for biological tissue repair.
J Mech Behav Biomed Mater
January 2025
Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom. Electronic address:
This study investigates the mechanical behaviour of poly(ɛ-caprolactone) (PCL) continuous filaments produced by a novel electrospinning (ES) method. These filaments can be processed into woven or braided structures, showing great promises as scaffolds for ligament and tendon repair. Mechanical characterisation of the filaments using DMA and uniaxial tensile tests shows that the filament response is viscoelastic-viscoplastic.
View Article and Find Full Text PDFIon channels are targeted by many drugs for treating neurological, musculoskeletal, renal and other diseases. These drugs bind to and alter the function of individual channels to achieve desired therapeutic effects. However, many ion channels function in high concentration clusters in their native environment.
View Article and Find Full Text PDFCrack propagation in TPMS scaffolds under monotonic axial load: Effect of morphology.
Med Eng Phys
October 2024
Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.
Article Synopsis
- The study examines how porous additively manufactured polylactide (PLA) scaffolds, designed with triply periodic minimal surfaces (TPMS), behave under stress and where they are likely to fail.
- It focuses on the strain-amplification factor and identifies the most critical failure points based on numerical simulations and comparisons with a crack-growth algorithm using the extended finite element method (XFEM).
- The research also evaluates how the morphology of the scaffolds affects their performance during different loading conditions, offering insights into fracture behaviors and risk areas for crack initiation in AM-PLA scaffolds.
Rupture mechanics of blood clots: Influence of fibrin network structure on the rupture resistance.
Acta Biomater
December 2024
Department of Biomedical Engineering, Rutgers University, NJ, USA. Electronic address:
Article Synopsis
- Embolization is a significant health issue, and while we understand that fibrin is crucial for blood clot stability, the mechanics of clot rupture are not fully understood.
- Research indicates that altering thrombin or tissue factor (TF) concentrations affects the structure and toughness of blood clots, but their specific impact on rupture resistance hasn't been explored in depth.
- The study found that increasing TF concentration improved fibrin toughness up to a certain point, revealing a complex relationship that emphasizes the need for understanding fibrin network structure to predict embolization risks better.
A Comprehensive Mechanical Characterization of Subject-Specific 3D Printed Scaffolds Mimicking Trabecular Bone Architecture Biomechanics.
Life (Basel)
October 2023
Materials Science and Engineering School, Tecnológico de Costa Rica, Cartago 30109, Costa Rica.
This study presents a polymeric scaffold designed and manufactured to mimic the structure and mechanical compressive characteristics of trabecular bone. The morphological parameters and mechanical behavior of the scaffold were studied and compared with trabecular bone from bovine iliac crest. Its mechanical properties, such as modulus of elasticity and yield strength, were studied under a three-step monotonic compressive test.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!