AI Article Synopsis
- The study highlights a shift in immunology focus from adaptive immune cells to the role of myeloid cells in tumors like glioblastoma, which lack T cells and are dominated by immunosuppressive cells.
- It discusses potential therapeutic strategies targeting myeloid-specific immune checkpoints, alongside some shared targets with adaptive immunity.
- By reviewing existing research on the effects of various immune checkpoint pathways, the authors aim to identify and prioritize new treatment options for glioblastoma.
Article Abstract
The field of immunology has traditionally focused on immune checkpoint modulation of adaptive immune cells. However, many malignancies such as glioblastoma are mostly devoid of T cells and rather are enriched with immunosuppressive myeloid cells of the innate immune system. While some immune checkpoint targets are shared between adaptive and innate immunity, myeloid-specific checkpoints could also serve as potential therapeutics. To better understand the impact of immune checkpoint blockade on myeloid cells, we systematically summarize the current literature focusing on the direct immunological effects of PD-L1/PD-1, CD24/Siglec-10, collagen/LAIR-1, CX3CL1/CX3CR1, and CXCL10/CXCR3. By synthesizing the molecular mechanisms and the translational implications, we aim to prioritize agents in this category of therapeutics for glioblastoma.
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| http://dx.doi.org/10.1093/neuonc/noae193 | DOI Listing |
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