Among the most important merits of modern missing data techniques such as multiple imputation (MI) and full-information maximum likelihood estimation is the possibility to include additional information about the missingness process via auxiliary variables. During the past decade, the choice of auxiliary variables has been investigated under a variety of different conditions and more recent research points to the potentially biasing effect of certain auxiliary variables, particularly colliders (Thoemmes & Rose, 2014). In this article, we further extend biasing mechanisms of certain auxiliary variables considered in previous research and thereby focus on their effects on individual diagnosis based on norming, in which the whole distribution of a variable is of interest rather than average coefficients (e.g., means). For this, we first provide the theoretical underpinnings of the mechanisms under study and then provide two focused simulations that (i) directly expand on the collider scenario in Thoemmes and Rose (2014, appendix A) by considering outcomes that are relevant to norming and (ii) extend the scenarios under consideration by instrumental variable mechanisms. We illustrate the bias mechanisms for two different norming approaches and exemplify the procedures by means of an empirical example. We end by discussing limitations and implications of our research.
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http://dx.doi.org/10.1080/00273171.2024.2412682 | DOI Listing |
J Chem Inf Model
January 2025
School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
The accurate identification of protein-nucleotide binding residues is crucial for protein function annotation and drug discovery. Numerous computational methods have been proposed to predict these binding residues, achieving remarkable performance. However, due to the limited availability and high variability of nucleotides, predicting binding residues for diverse nucleotides remains a significant challenge.
View Article and Find Full Text PDFBackground: The present study examined OSA using an objective home sleep test in 81 adults with DS (aged 25 ∼ 61 years) and evaluated associations between sleep-disordered breathing problems and biomarkers of AD pathology (PET Aβ and tau) and symptomology (cognitive performance and depressed mood).
Method: As part of the ABC-DS study, participants completed a 2.5-hour battery of cognitive measures and underwent MRI and PET imaging scans and a blood draw.
Background: Mild Cognitive Impairment (MCI) is considered as a transitional state between age-related cognitive decline and dementia. Accurate prediction of those at risk of MCI is important for timely intervention and treatment of Alzheimer's disease. In this study, we show that incorporating the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) with rich resources from Electronic Health Records (EHR), including comorbidities and medication histories, can achieve higher prediction accuracy, compared to using only one resource.
View Article and Find Full Text PDFEvid Based Dent
January 2025
Department of Paediatric and Preventive Dentistry I.T.S Dental College, Hospital and Research Centre, Greater Noida, Uttar Pradesh, India.
Aims/objectives: This systematic review aimed to evaluate the effectiveness of auxiliary aids-Transcutaneous Electrical Nerve Stimulation (TENS), vibrotactile devices, and Low-Level Laser Therapy (LLLT) in reducing pain and anxiety during dental local anesthesia in pediatric patients.
Methods: The review followed PRISMA guidelines, employing a comprehensive search strategy across multiple databases (PubMed, Cochrane, EBSCO, LILACS, Google Scholar, and Embase) from 2014 to July 2024. Eligibility criteria were based on the PICOS framework, focusing on randomized clinical trials and clinical studies involving pediatric patients undergoing dental procedures with local anesthesia.
Homelessness is a growing concern in the United States, especially among people who use drugs (PWUD). The degree of material hardship among this population may be linked to worse health outcomes. PWUD experiencing homelessness in urban areas are increasingly subjected to policies and social treatment, such as forced displacement, which may worsen material hardship.
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