AI Article Synopsis
- The study aimed to evaluate the effectiveness of HeXue Tongbi Formula in treating peripheral neuropathy caused by oxaliplatin chemotherapy in cancer patients.
- Conducted with 78 participants, half received the HeXue Tongbi Formula while the other half served as a control, with results showing significantly lower rates of neuropathy in the treatment group after four cycles.
- The findings suggest that HeXue Tongbi Formula is effective in preventing and treating peripheral neuropathy, with no serious side effects reported.
Article Abstract
Aim: The aim of this study was to analyse the effiacy of HeXue Tongbi Formula in the treatment of oxaliplatin-induced perpheral neuropathy.
Method: An open randomized, non-blind, controlled study was conducted at the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from September 2019 to December 2020. A total of 78 maligant tumor patients receiving oxaliplatin-containing chemotherapy were recruited, with half of them receiving HeXue Tongbi Formula for 4 cycles of 21 days. The study assessed the incidence and severity of perpheral neuropathy and the safety of HeXue Tongbi Formula.
Result: After 4 cycles of treatment, the incidence of perpheral neuropathy in the treatment group was significantly lower than that in the control group (30.77% versus 84.62%, < .05). The severity of perpheral neuropathy in the treatment group increased sligthly and stabilized from the third cycle, whlie it gradually increased in the control group. yhere were no severe adverse reactions to HeXue Tongbi Formula.
Conclusion: HeXue Tongbi Formula demonstrated good preventive and therapeutic effects on oxaliplatin-induced perpheral neuropathy.
Trial Registration: This trial has been registered with the Chinese Clinical Trial Registry (ChiCTR2000032996).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503713 | PMC |
| http://dx.doi.org/10.1177/15347354241291514 | DOI Listing |
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