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Growth performance, carcass traits, meat composition, digestibility coefficients and caecal microbiota of growing rabbits fed diets supplemented with a herbal mixture.
Trop Anim Health Prod
January 2025
Animal and Poultry Production Department, Faculty of Technology and Development, Zagazig University, Zagazig, 44519, Egypt.
The study investigates the effect of dietary herbal mixture (HM) levels on growing New Zealand White (NZW) rabbits' performance, carcass characteristics, blood biochemicals, and microbiological characteristics from 5 to 13 weeks of age. In this study, 96 New Zealand White rabbits (male and female ratio 1:1) were used, and they were five weeks old. The rabbits were at random allocated into four experimental groups (n = 24 each) comprising 12 replicates, each with two rabbits.
View Article and Find Full Text PDFPolyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes.
FASEB J
January 2025
Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Osteoarthritis (OA) is characterized by articular cartilage degeneration, leading to pain and loss of joint function. Recent studies have demonstrated that omega-3 (ω3) polyunsaturated fatty acid (PUFA) supplementation can decrease injury-induced OA progression in mice fed a high-fat diet. Furthermore, PUFAs have been shown to influence the mechanical properties of chondrocyte membranes, suggesting that alterations in mechanosensitive ion channel signaling could contribute to the mechanism by which ω3 PUFAs decreased OA pathogenesis.
View Article and Find Full Text PDFNovel insights into the role of gut microbiota and its metabolites in diabetic chronic wounds.
FASEB J
January 2025
Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P.R. China.
Wounds in patients with diabetes present significant physical and economic challenges due to impaired healing and prolonged inflammation, exacerbated by complex interactions between microbes. Especially, the development and healing of diabetic foot ulcers (DFUs) remain an urgent clinical problem. The human gut harbors a vast microbial ecosystem comprising intestinal flora and their metabolic products.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Saint John's Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.
Background: Medical management and lifestyle are potentially crucial interventions for Alzheimer's disease (AD). In this study, we present the relationship between adherence of a personalized multi-modal intervention for AD on change in cerebral blood flow (CBF) after 12-months.
Methods: The PREVENTION study is an ongoing randomized clinical trial (McEwen, 2001).
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Alzheimers Dement
December 2024
University of Kansas Medical Center, Kansas City, KS, USA.
Background: Diminished muscle function and strength are linked to an increased risk and accelerated progression of Alzheimer's disease (AD). Although these are direct consequences of the disease, recent preclinical evidence suggests decreased muscle function and strength may directly influence AD risk and progression via the muscle-brain axis. Therefore, interventions to improve muscle strength may prevent functional decline related to AD.
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