AI Article Synopsis
- This scoping review investigated the use of Low-Level Laser Therapy (LLLT) for treating and preventing osteoradionecrosis, analyzing trends and existing evidence across various studies.
- A total of 19 studies were included, revealing that most LLLT applications were therapeutic (58%), with a smaller portion for preventive use (21%).
- The findings highlighted a lack of standardization in laser parameters, indicating a need for further research to establish consistent treatment protocols and to conduct larger, well-designed clinical trials to assess LLLT's effectiveness more reliably.
Article Abstract
Background: This scoping review explored current trends and available evidence in Low-Level Laser Therapy (LLLT) in the treatment and prevention of osteoradionecrosis.
Methods: The search strategy was conducted in MEDLINE/PubMed, EMBASE, Web of Science, and grey literature on January 15, 2024, without language or time restrictions.
Results: 19 studies were included. The application of LLLT protocols was 58 % for therapeutic use, 21 % for preventive use, and 21 % for a combination of both. Regarding the use of antimicrobial photodynamic therapy (aPDT), 41 % of the studies employed this technique, which utilized methylene blue as the photosensitizer. For treatments associated with photobiomodulation, 57 % reported pharmacological treatment, 29 % surgical treatment, 11 % prescribed chlorhexidine mouthwashes, and 4 % other therapies. In vivo studies used diode lasers emitting low incident power densities in the near-infrared wavelength (67 %) at 780 to 904 nm. In comparison, case reports also used diode lasers emitting low incident power densities in the red and near-infrared wavelength (64 %) at 660 to 904 nm. The continuous emission mode was utilized in 83 % of in vivo studies and 17 % of the case reports. None of the studies included in this review reported all laser parameters.
Conclusions: In general, studies suggested that LLLT can be used for therapeutic and preventive applications in the management of osteoradionecrosis. However, clinical studies are case reports and the variability in laser parameters across the included studies poses challenges for establishing standardized treatment protocols. The lack of comprehensive data on laser parameters underscores the need for future research to focus on standardizing LLLT protocols and conducting well-designed, large-scale clinical trials. This approach will help to better evaluate the effectiveness of LLLT and potentially integrate it more reliably into clinical practice.
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| http://dx.doi.org/10.1016/j.pdpdt.2024.104381 | DOI Listing |
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