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Final CONUS Results on Coherent Elastic Neutrino-Nucleus Scattering at the Brokdorf Reactor.
Phys Rev Lett
December 2024
PreussenElektra GmbH, Kernkraftwerk Brokdorf GmbH & Co. oHG, Osterende, 25576 Brokdorf, Germany.
The CONUS experiment studies coherent elastic neutrino-nucleus scattering in four 1 kg germanium spectrometers. Low ionization energy thresholds of 210 eV were achieved. The detectors were operated inside an optimized shield at the Brokdorf nuclear power plant which provided a reactor antineutrino flux of up to 2.
View Article and Find Full Text PDFPmiR-Select - a computational approach to plant pre-miRNA identification in genomes.
Mol Genet Genomics
January 2025
Department of Botany, Biology Institute, UnB, Brasília, DF, 70910-900, Brazil.
Precursors of microRNAs (pre-miRNAs) are less used in silico to mine miRNAs. This study developed PmiR-Select based on covariance models (CMs) to identify new pre-miRNAs, detecting conserved secondary structural features across RNA sequences and eliminating the redundancy. The pipeline preceded PmiR-Select filtered 20% plant pre-miRNAs (from 38589 to 8677) from miRBase.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Background: A polygenic risk score (PRS) estimates an individual's genetic liability for diseases based on accumulated genetic variations. While the PRS has been shown to contribute to the prediction of dementia risk, its utility in predicting the effectiveness of multifactorial interventions to reduce the risk of dementia remains unclear.
Methods: A genome-wide association study (GWAS) was conducted to identify dementia-related traits in the Japanese population.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Background: Classical genome-wide association studies (GWAS) of Alzheimer's disease (AD), which successfully identified over 75 risk loci to date, are limited to the content of the imputation panels that typically do not cover all types of genetic variation, e.g., tandem repeats encompassing >55% of human genome.
View Article and Find Full Text PDFTheoretical Coupling of Free-Flowing Ions and Magnetically Insulated Electrons.
Phys Rev Lett
December 2024
Sandia National Laboratories, PO Box 5800, Albuquerque, New Mexico 87185, USA.
Magnetic insulation of electrons prevents losses and can be applied to generating radiation or electron sources for high current and high power applications. Ion emission from the anode may degrade magnetic insulation. We develop equilibrium theory, self-consistently coupling magnetically insulated electron flow with free-flowing injected ions.
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