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Background: Annually, tropical diseases are a major cause of mortality; for instance, in 2019, neglected tropical diseases (NTDs) caused 150,000 deaths and 19 million DALYs, with sub-Saharan Africa bearing over half the burden and the other concentrations in Asia and South America. Their impact, though significant, is lower than ischemic heart disease and respiratory infections. The World Health Organization is critical in combating these tropical diseases through surveillance, information campaigns and health promotion.
View Article and Find Full Text PDFA journey worth taking: global eradication of measles, rubella and congenital rubella syndrome.
Expert Rev Vaccines
December 2025
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Global withdrawal of Sabin oral poliovirus type 2 vaccine in 2016.
Science
March 2025
SESB members and their affiliations are listed at the end of this article.
Evaluation guides strategy for the polio eradication endgame.
View Article and Find Full Text PDFLeveraging implementation science in clinical trials of vaccines in the global south.
Nat Med
March 2025
Vaccine-Preventable Diseases Programme, World Health Organization Regional Office for Africa, Brazzaville, Congo.
Sabin inactivated polio vaccine upstream process development using fixed-bed bioreactor technology.
Vaccine
March 2025
Batavia Biosciences B.V., Bioscience Park Leiden, Zernikedreef 16, 2333CL, Leiden, the Netherlands. Electronic address:
Eradication of polio disease remains a challenge for countries with limited health-care infrastructure. Regional vaccine production is expected to secure a sustainable and equitable availability of vaccines supporting the polio eradication end-game. Regional manufacturing of Inactivated Polio Vaccines based on the attenuated Sabin strains and using an isolator-based contained micro-facility is expected to avoid any potential risk of shortage of polio vaccines in the future, ensure equitable access to sufficient doses of IPV while securing a safe manufacturing environment.
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