Background: Older adults are particularly vulnerable to experiencing hospital-associated functional decline; a multifaceted phenomenon linked to poorer outcomes and increased healthcare costs. Given that functionality serves as a crucial indicator of health in the elderly, various scales have been developed to gauge the continuum of functional ability, potentially serving as prognostic tools to inform tailored interventions.
Objectives: The aim of this study is to determine the prevalence of hospital-associated functional decline in an acute geriatric unit and examine its correlation with the functional continuum through a descriptive analysis of the patient population and exploration of associated factors.
Results: 142 patients aged 75 and above were included in the analysis, revealing that 57% exhibited hospital-associated functional decline. Among patients with functional impairment, 26% fell into category 4 (dependence for instrumental activities of daily living and pre-frailty). Among the factors examined, age (OR 1.280, 95% CI 1.099 - 1.547) and prior independence (OR 15.939, 95% CI 1.857 - 186.655) were found to be associated with hospital functional decline.
Conclusion: Hospital-associated functional decline was observed in over half of the patients, with age and prior independence identified as significant contributing factors. This underscores the importance of implementing intervention measures for all elderly patients during their hospitalization, particularly for frail or pre-frail individuals with some level of instrumental dependency.
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http://dx.doi.org/10.1016/j.regg.2024.101564 | DOI Listing |
Phys Ther
December 2024
Eastern Colorado VA Health Care System, Geriatric Research Education and Clinical Center (GRECC), Aurora, CO, United States.
Objective: The optimal approach for improving physical function following acute hospitalization is unknown. A recent clinical trial of home health physical therapy compared a high-intensity, progressive, multi-component (PMC) intervention to enhanced usual care (EUC). While both groups improved in physical function, no between-group differences were observed.
View Article and Find Full Text PDFPhys Ther
December 2024
Eastern Colorado VA Health Care System, Geriatric Research Education and Clinical Center (GRECC), Aurora, CO, United States.
Objectives: Reduced physical function following hospitalization places older adults at risk of adverse health events. Many older adults receive home health physical therapy to reverse their deconditioning; however, optimal approaches to improve physical function are currently not known. This study aimed to evaluate the effectiveness of a home health care approach comprised of high-intensity exercise, enhanced care transition, and protein supplementation.
View Article and Find Full Text PDFJ Bacteriol
December 2024
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Vancomycin-resistant enterococci (VRE) are important pathogens in hospitalized patients; however, the factors involved in VRE colonization of hospitalized patients are not well characterized. Bacteriocins provide a competitive advantage to enterococci in experimental models of colonization, but little is known about bacteriocin content in samples derived from humans and even less is known about their dynamics in the clinical setting. To identify bacteriocins which may be relevant in the transmission of VRE, we present a systematic analysis of bacteriocin content in the genomes of 2,248 patient-derived isolates collected over a 6-year period from a single hospital system.
View Article and Find Full Text PDFInfect Genet Evol
December 2024
Duke-Ruhuna Collaborative Research Centre, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka; Duke Global Health Institute, Durham, NC, USA; Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Int J Mol Sci
November 2024
Neurofarba Department, Section of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.
is a Gram-negative opportunistic pathogen responsible for severe hospital-associated infections. Owing to its ability to develop resistance to a wide range of antibiotics, novel therapeutic strategies are urgently needed. One promising approach is to target bacterial carbonic anhydrases (CAs; EC 4.
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