AI Article Synopsis
- Calcium- and integrin-binding protein 1 (CIB1) plays key roles in various cellular functions like calcium signaling, cell migration, and adhesion, and is linked to diseases such as cancer and cardiovascular issues.
- Researchers used CRISPR/Cas9 technology to create a CIB1 knockout human embryonic stem cell line.
- The resulting stem cell line maintained normal pluripotency and karyotype, indicating it still has the ability to differentiate into various cell types.
Article Abstract
Calcium- and integrin-binding protein 1 (CIB1) has a diverse role in many different cell types and processes, including calcium signaling, migration, adhesion, proliferation, and survival. It is associated with cancer, cardiovascular disease and male infertility. Here, CRISPR/Cas9 genome-editing technology was employed to establish a CIB1 knockout human embryonic stem cell line, which exhibited normal pluripotency and karyotype.
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| http://dx.doi.org/10.1016/j.scr.2024.103580 | DOI Listing |
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