We report on the first systematic characterization of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10-20 ps in a single irradiation, thus reaching unprecedented dose rates in the range of 10^{10}-10^{12} Gy/s. Detailed characterization of the source indicates, in agreement with Monte Carlo simulations, dose delivery over cm-scale areas with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultrahigh dose rates.
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http://dx.doi.org/10.1103/PhysRevE.110.035204 | DOI Listing |
Health Phys
January 2025
Department of Radiation Oncology, Medicine Faculty of Van Yüzüncü Yıl University, Van, Turkey.
Quality assurance practices performed before treatment are believed to identify various potential errors. In this study, 2-dimensional (2D) dosimetric results were analyzed by making some intentional mistakes in six different treatment plans. In this way, the detectability of errors was investigated.
View Article and Find Full Text PDFJ Occup Environ Hyg
January 2025
Finance Department, University of Texas at Austin, Austin, Texas.
This paper asserts that the Nobel Prize for Medicine/Physiology that Hermann J. Muller received in 1946 was a front to enhance the legitimacy, acceptance, and application of eugenics, a strategy to guide the direction and rate of human evolutionary change. Seven of the nine people nominating (1932-1946) Muller were proponents of eugenics with Muller being among the most visible of the scientific leaders.
View Article and Find Full Text PDFBlood
January 2025
Brigham and Women's Hospital, Boston, Massachusetts, United States.
High-dose methotrexate (MTX) results in high rates of acute kidney injury (AKI), neutropenia, and hepatotoxicity. Glucarpidase is a recombinant enzyme that cleaves MTX, but clinical data supporting its use are scarce. We examined the association between glucarpidase administration and outcomes in adults with MTX-AKI from 28 cancer centers across the U.
View Article and Find Full Text PDFRadiat Environ Biophys
January 2025
Department of Pharmacology, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India.
Radiation therapy (RT) is fundamental to the fight against cancer because of its exceptional ability to target and destroy cancer cells. However, conventional radiation therapy can significantly affect the adjacent normal tissues, leading to fibrosis, inflammation, and decreased organ function. This tissue damage not only reduces the quality of life but also prevents the total elimination of cancer.
View Article and Find Full Text PDFAndes Pediatr
August 2024
Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.
Unlabelled: Palivizumab, a humanized monoclonal antibody against the respiratory syncytial virus (RSV), currently is indicated in groups at higher risk of developing severe RSV disease, such as extreme premature infants and patients with hemodynamically significant heart disease. In Chile, this strategy is guaranteed by Law 20850 (Ricarte Soto Law). Nevertheless, barriers to its administration included the need to transfer these labile patients and exposure to other users, with the risk of contagion in waiting rooms.
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