AI Article Synopsis
- - Analyzed the link between plasma fibrinogen levels and the incidence of pulmonary infection (PI) in patients with spinal cord injuries (SCI), highlighting that these patients are particularly vulnerable to infections.
- - Reviewed data from 491 SCI patients, identifying that for each 1 g/L increase in fibrinogen, the risk of developing PI rose by 18%, suggesting a direct relationship between fibrinogen levels and infection risk.
- - Concluded that plasma fibrinogen is an independent risk factor for PI, especially in patients with AIS-B and C grades, indicating that monitoring and managing fibrinogen levels could help reduce infection rates in SCI patients.
Article Abstract
Background: Patients with spinal cord injury (SCI) are at higher risk of developing pulmonary infection (PI), and plasma fibrinogen level may be an independent risk factor for PI. However, the relationship between fibrinogen level and PI incidence in the SCI population remains unclear. This study aimed to elucidate the association between plasma fibrinogen level and the occurrence of PI among SCI patients.
Methods: We conducted a retrospective analysis of 576 SCI patients admitted to the Rehabilitation Medicine Department between January 1, 2017, and December 31, 2021. Following exclusions, 491 patients were included in the final analysis, with 139 PI cases identified.
Results: Surgery, level of injury and chest comorbidities were covariates in the relationship between fibrinogen level and PI incidence. Other identified potential risk factors for PI included age, D-dimer level, urinary tract infections (UTI), deep vein thrombosis (DVT), anticoagulant therapy, injury mechanism, and the American Spinal Injury Association Impairment Scale (AIS) grades. After adjusting for these factors, we found that for every 1 g/L increase in fibrinogen level, the risk of developing PI increased by 18% (HR = 1.18, P = 0.011), and indicating a positive linear relationship between fibrinogen level and PI incidence.
Conclusion: Plasma fibrinogen was an independent risk factor for PI in patients with SCI, especially for AIS-B and C grades. Proactive management of fibrinogen level after admission to rehabilitation medicine department could be crucial in reducing the incidence of PI in this vulnerable population.
Clinical Trial Number: Not applicable.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487796 | PMC |
| http://dx.doi.org/10.1186/s12890-024-03332-y | DOI Listing |
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