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The new age of the phage.
Essays Biochem
December 2024
Structural & Molecular Biology, Division of Biosciences, UCL, London, U.K.
The discovery of viruses that can devour bacteria, bacteriophages (phages), was in 1915. Phages are ubiquitous, outnumbering the organisms they devour, and genomically, morphologically, and ecologically diverse. They were critical in our development of molecular biology and biotechnology tools and have been used as therapeutics for over 100 years, primarily in Eastern Europe with thousands of patients from all over the world treated in Georgia.
View Article and Find Full Text PDFRegional Differences in Job Satisfaction among Chinese Social Workers: The Mediating Effect of Attitudinal Professionalism.
Soc Work
November 2024
Yihong Xia, MPhil, RSW, is a social worker, Hong Kong Polytechnic University, Hong Kong, China.
Job satisfaction is a vital factor associated with better physical health and subjective well-being among social workers. This study aims to explore the job satisfaction of social workers from China's Mainland and Macao and the role of attitudinal professionalism on regional differences. A cross-sectional survey collected data from 292 social workers in Mainland and 108 from Macao one year after the outbreak of COVID-19; 72 percent were female, less than half were married (44.
View Article and Find Full Text PDFThe Dawning of a New Age of Preclinical Analgesic Drug Screening.
J Pharmacol Exp Ther
October 2024
Washington State University Vancouver, Vancouver, Washington
Prediction of coronary artery lesions in children with Kawasaki syndrome based on machine learning.
BMC Pediatr
March 2024
Heart Center, Qingdao Women and Children's Hospital, Qingdao University, Qingdao, China.
Objective: Kawasaki syndrome (KS) is an acute vasculitis that affects children < 5 years of age and leads to coronary artery lesions (CAL) in about 20-25% of untreated cases. Machine learning (ML) is a branch of artificial intelligence (AI) that integrates complex data sets on a large scale and uses huge data to predict future events. The purpose of the present study was to use ML to present the model for early risk assessment of CAL in children with KS by different algorithms.
View Article and Find Full Text PDFAnti-amyloid antibody treatments for Alzheimer's disease.
Eur J Neurol
February 2024
Department of Neurology, Inselspital, University of Bern, Bern, Switzerland.
Our aim is to review the most recent evidence on novel antibody therapies for Alzheimer's disease directed against amyloid-β. This is a joint statement of the European Association of Neurology and the European Psychiatric Association. After numerous unsuccessful endeavors to create a disease-modifying therapy for Alzheimer's disease, substantial and consistent evidence supporting the clinical effectiveness of monoclonal antibodies aimed at amyloid-β is finally emerging.
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