AI Article Synopsis
- * Results show a 100% viral suppression rate and significant increases in CD4+ T cell counts after transitioning to these therapies over a 6-month period.
- * The therapies are deemed safe, with improvements in certain health indicators (like LDL and HDL levels) and reductions in ALT, AST, and blood glucose levels, affirming their recommendation for HIV/AIDS treatment.
Article Abstract
Aims: Genvoya, Biktarvy and Dovato are novel single-tablet antiretroviral therapy(ART). The aim of this study is to explore the therapeutic effects of these novel drugs on HIV/AIDS.
Main Methods: This retrospective cohort study, conducted at a single center, included a total of 200 HIV-treated patients who transitioned to these new antiretroviral drugs from July 2021 to August 2023. Data were extracted from electronic medical records at Ditan Hospital. The Genvoya group comprised 22 patients, and all subsequent switches in this group were to Biktarvy. The primary HAART group consisted of 178 patients initially treated with a first-line triple Highly Active Antiretroviral Therapy (HAART) regimen during the same period. This group was further subdivided into HAART+Dovato, HAART+Biktarvy, and HAART+Genvoya groups based on the switching regimen. The primary outcomes focused on changes in viral load and immune efficacy, while secondary safety indicators included blood/liver function, lipid parameters, renal function, blood glucose, blood uric acid, etc. KEY FINDINGS: The viral suppression rate was 100 % after the drug change treatment, and CD4+ T cell counts increased significantly across all four groups. Over the 6-month treatment period, there were increases in creatinine (Cr), low-density lipoprotein (LDL), high-density lipoprotein (HDL), erythrocyte count, and glomerular filtration rate (eGFR). Conversely, Alanine transaminase (ALT), Aspartate aminotransferase (AST), C-reactive protein (CRP), albumin (ALB), and blood glucose (Glu) levels decreased.
Significance: Genvoya, Biktarvy and Dovato are recommended for the treatment of HIV/AIDS and have a good safety profile.
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| http://dx.doi.org/10.1016/j.lfs.2024.123117 | DOI Listing |
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