AI Article Synopsis
- * When lncRNAs are dysregulated, they can either promote cancer as oncogenes or inhibit it as tumor suppressors, affecting tumor progression and characteristics like metastasis and chemoresistance.
- * The review emphasizes the need to understand lncRNAs' roles in cancer to develop new therapeutic strategies and enhance precision medicine approaches in treating cancer patients.
Article Abstract
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of epigenome, modulating gene expression through DNA methylation, histone modification, and/or chromosome remodeling. Dysregulated lncRNAs act as oncogenes or tumor suppressors, driving tumor progression by shaping the cancer epigenome. By interacting with the writers, readers, and erasers of the epigenetic script, lncRNAs induce epigenetic modifications that bring about changes in cancer cell proliferation, apoptosis, epithelial-mesenchymal transition, migration, invasion, metastasis, cancer stemness and chemoresistance. This review analyzes and discusses the multifaceted role of lncRNAs in cancer pathobiology, from cancer genesis and progression through metastasis and therapy resistance. It also explores the therapeutic potential of targeting lncRNAs through innovative diagnostic, prognostic, and therapeutic strategies. Understanding the dynamic interplay between lncRNAs and epigenome is crucial for developing personalized therapeutic strategies, offering new avenues for precision cancer medicine.
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| http://dx.doi.org/10.1016/j.canlet.2024.217297 | DOI Listing |
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