AI Article Synopsis
- Park et al. found that interleukin (IL)-1α plays a crucial role in amplifying the effects of inflammaging, which is the chronic inflammation associated with aging.
- The study revealed that aging leads to reduced levels of DNMT3A, resulting in increased production of IL-1α in lung myeloid cells.
- This heightened IL-1α production promotes emergency myelopoiesis in the bone marrow, which enhances immunosuppression in tumors, facilitating tumor growth in older mice.
Article Abstract
In a Science paper, Park et al. identified interleukin (IL)-1α as a key driver of positive feedback in inflammaging, linking aging-associated downregulation of DNMT3A to increased IL-1α production in lung myeloid cells. This triggers emergency myelopoiesis in the bone marrow, amplifying myeloid-mediated intratumoral immunosuppression for tumor progression in aged mice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ccell.2024.09.015 | DOI Listing |
Publication Analysis
Top Keywords
il-1 signaling
4
signaling aging
4
aging cancer
4
cancer inflammaging
4
inflammaging feedback
4
feedback loop
4
loop unveiled
4
unveiled science
4
science paper
4
paper park
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!