In a recent study in Cell, Lascaux et al. implicate TEX264 in the autophagy-driven resolution of nuclear topoisomerase 1 cleavage complexes (TOP1cc) in lysosomes, altering current concepts on the mechanism of action for clinically relevant doses of TOP1 inhibitors.
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| http://dx.doi.org/10.1016/j.molcel.2024.09.021 | DOI Listing |
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Positioning of the Inferior Alveolar Nerve and Surgical Implications: A Study on Thai Mandibles.
Ann Plast Surg
December 2024
From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine.
Background: The inferior alveolar nerve (IAN), a crucial branch of the trigeminal nerve, innervates the mandible. Precise knowledge of IAN positioning ensures surgical safety.
Methods: This cross-sectional study analyzed head and neck computed tomography scans from Maharaj Nakorn Chiang Mai Hospital.
Exploring Awareness Levels of Diabetic Ketoacidosis Risk Among Patients with Diabetes: A Cross-Sectional Study.
Clin Pract
December 2024
Center for Health Research, Northern Border University, Arar 91431, Saudi Arabia.
: Diabetic ketoacidosis (DKA) is a critical complication of diabetes mellitus, posing significant health. While global studies have indicated a concerning lack of awareness regarding DKA among patients with diabetes, research specific to the northern area of Saudi Arabia remains limited. This study aims to explore the level of knowledge and awareness of DKA among patients with diabetes residing in the local region.
View Article and Find Full Text PDFUltra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity.
JAMA Ophthalmol
December 2024
Casey Eye Institute, Oregon Health and Science University, Portland.
Importance: Capturing high-quality images of the entire peripheral retina while minimizing the use of scleral depression could increase the quality of examinations for retinopathy of prematurity (ROP) while reducing neonatal stress.
Objective: To evaluate whether an investigational handheld ultra-widefield optical coherence tomography (UWF-OCT) device without scleral depression can be used to document high-quality images of the peripheral retina for use in ROP examinations.
Design, Setting, And Participants: This was a prospective, cross-sectional study in the neonatal intensive care unit at a single academic medical center.
Comparison Between Single- and Multi-slice Computed Tomography Body Composition Analysis in Patients With Oesophagogastric Cancer.
J Cachexia Sarcopenia Muscle
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Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK.
Article Synopsis
- This study investigates the effectiveness of single-slice versus multi-slice computed tomography (CT) methods in analyzing body composition in patients with oesophagogastric cancer, focusing on their correlation and impact on survival rates.
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Integrated Multidisciplinary Approach to Acute Chest Pain: Perspectives From Family Medicine, Emergency Medicine, and Internal Medicine.
Cureus
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Internal Medicine, Hayatabad Medical Complex, Peshawar, PAK.
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Objective: This study aimed to explore and evaluate the perspectives of healthcare professionals in family, emergency, and internal medicine regarding the management of acute chest pain, with a specific focus on diagnostic practices, interdisciplinary collaboration, and protocol adherence to establish best practices for a unified approach.
Methodology: This cross-sectional study, conducted from June 2022 to July 2024, included 218 healthcare professionals with over a year of experience in family, emergency, and internal medicine, selected through convenient sampling from hospitals such as Lady Reading Hospital, Hayatabad Medical Complex, Mardan Medical Complex, and Government Mian Meer Hospital.
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