AI Article Synopsis
- - Schizophrenia is a major mental disorder that significantly impacts daily functioning and well-being.
- - Induced pluripotent stem cells (iPSCs) can be created from patients with ultra-treatment-resistant schizophrenia, allowing researchers to study the disease more effectively.
- - These iPSCs maintain the patient's genetic traits and can differentiate into various cell types, making them a valuable tool for understanding schizophrenia mechanisms and testing new treatments.
Article Abstract
Schizophrenia is a severe mental illness with disabling effects. Induced pluripotent stem cells (iPSCs) are generated by reprogramming peripheral blood mononuclear cells (PBMCs) from patients with ultra-treatment-resistant schizophrenia (UTRS). iPSCs have normal karyotype, express pluripotency markers and differentiate into three germ layers in vivo. This iPSC cell line carries the genetic information of the patient and is a good model for studying disease mechanisms and developing new therapies.
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| http://dx.doi.org/10.1016/j.scr.2024.103575 | DOI Listing |
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