Relativistic electron bunches used to produce synchrotron radiation are systematically subjected to spontaneous appearance of microstructures, when a high number of electrons are used. In storage rings, this usually leads to an intense coherent emission in the terahetz range, with powers that are orders of magnitude higher than standard incoherent emission. However this emission generally displays an erratic behavior, which has strongly limited its domain of application so far. In this Letter-inspired by the process of gain switching in lasers-we present a new method for controlling the electron bunch dynamics during this instability. We show that it is possible to trigger the formation of the microstructures in the bunch, and also to considerably enhance the peak power of the coherent terahertz bursts. The experimental demonstration of this scheme-based on the modulation of a rf-cavity signal-is performed at the SOLEIL facility.
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http://dx.doi.org/10.1103/PhysRevLett.133.145001 | DOI Listing |
Sci Rep
December 2024
Department of Electrical and Electronics Engineering, Dr.N.G.P. Institute of Technology, Coimbatore, India.
Multiport converters are the most reliable and integral component for latest renewable source integration with multiple inputs. This article is one among the kind, which proposes a novel Coupled Inductor based Four Port topology Multiport Converter (CI-FP-MPC) for integrating multiple PV sources with different voltages. The adoption of coupled inductor contributes an increased voltage gain with reduced stress on the switches and diodes.
View Article and Find Full Text PDFSci Rep
December 2024
School of Computer and Artificial Intelligence, Beijing Technology and Business University, Beijing, 100048, China.
To achieve high-performance trajectory tracking for a manipulator, this study proposes a novel sliding mode control strategy incorporating a nonlinear disturbance observer. The observer is designed to estimate unknown models in real-time, enabling feedforward compensation for various uncertainties such as modeling errors, joint friction, and external torque disturbances. The control law is formulated by integrating the Backstepping method, Lyapunov theory, and global fast terminal sliding mode theory, ensuring global convergence to zero within finite time and enhancing system robustness.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Department of Biological Sciences, University of Memphis, Memphis, TN 38152, USA. Electronic address:
Mitogen-activated protein kinase kinase kinase 4 (MAP3K4) promotes fetal and placental growth and development, with MAP3K4 kinase inactivation resulting in placental insufficiency and fetal growth restriction. MAP3K4 promotes key signaling pathways including JNK, p38, and PI3K/Akt, leading to activation of CREB-binding protein. MAP3K4 kinase inactivation results in loss of these pathways and gain of histone deacetylase 6 (HDAC6) expression and activity.
View Article and Find Full Text PDFPLoS One
December 2024
Instituto de Neurociencias CSIC-UMH, Universidad Miguel Hernandez, Sant Joan d'Alacant, Alicante, Spain.
Fasciclin 2 (Drosophila NCAM) is a homophilic Cell Adhesion Molecule expressed at moderate levels in the proliferating epithelial cells of imaginal discs, where it engages EGFR in a cell autonomous auto-stimulatory loop that promotes growth along larval development. In addition, Fasciclin 2 is expressed at high levels in the pre-differentiating cells of imaginal discs. Gain-of-function genetic analysis shows that Fasciclin 2 acts as a non-cell autonomous repressor of EGFR when high expression levels are induced during imaginal disc growth.
View Article and Find Full Text PDFDiabetes Obes Metab
December 2024
Sanofi Investment Co., Ltd., Shanghai, China.
Aims: To evaluate the efficacy and safety of insulin glargine 300 U/mL (Gla-300) in people with uncontrolled type 2 diabetes (T2D) switching from another basal insulin (BI).
Materials And Methods: INITIATION was an interventional, single-arm, phase IV study conducted in China. In this post hoc subpopulation analysis, the efficacy and safety of switching to Gla-300 was investigated in individuals with uncontrolled T2D (HbA1c 7.
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