Purpose: To investigate the changes in choroidal thickness (ChT), refractive status, and ocular dimensions in the mouse eye in vivo using updated techniques and instrumentation.
Methods: High-resolution swept-source optical coherence tomography (SS-OCT), eccentric infrared photoretinoscopy, and custom real-time optical coherence tomography were used to analyze choroidal changes, refractive changes and ocular growth in C57BL/6J mice from postnatal day (P) 21 to month 22.
Results: The ChT gradually increased with age, with the thickest region in the para-optic nerve head and thinning outward, and the temporal ChT was globally thicker than the nasal ChT. Retinal thickness remained stable until 4 months and subsequently decreased. The average spherical equivalent refraction error was -4.81 ± 2.71 diopters (D) at P21, which developed into emmetropia by P32, reached a hyperopic peak (+5.75 ± 1.38 D) at P82 and returned to +0.66 ± 1.86 D at 22 months. Central corneal thickness, anterior chamber depth, lens thickness, and axial length (AL) increased continuously before 4 months, but subsequently exhibited subtle changes. Vitreous chamber depth decreased with lens growth. ChT was correlated significantly with the ocular parameters (except for retinal thickness) before the age of 4 months, but these correlations diminished after 4 months. Furthermore, for mice younger than 4 months, the difference in the ChT, especially temporal ChT, between the two eyes contributed most to that of axial length and spherical equivalent refraction error.
Conclusions: Four months could be a watershed age in the growth of mouse eyes. Large-span temporal recordings of refraction, ocular dimensions, and choroidal changes provided references for the study of the physiological and pathological mechanisms responsible for myopia.
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http://dx.doi.org/10.1167/iovs.65.12.26 | DOI Listing |
Ophthalmic Plast Reconstr Surg
December 2024
Adnexal Department, Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom.
Purpose: Euryblepharon is a rare congenital eyelid malformation characterized by symmetrical horizontal enlargement of the palpebral fissure. The eyelid is shortened vertically compared with the horizontal dimension. The lateral canthus is most commonly affected.
View Article and Find Full Text PDFInt J Retina Vitreous
December 2024
Department of Biomedicine - Unit of Anatomy, Faculty of Medicine, University of Porto, Porto, Portugal.
Purpose: To assess the retinal microvasculature of Systemic Lupus Erythematosus (SLE) patients using Optical Coherence Tomography Angiography (OCTA).
Methods: Twenty adult SLE patients without disease activity and no ocular manifestations were recruited and cross-sectionally assessed. A demographically similar cohort of healthy subjects was used for comparison.
PLoS One
December 2024
Centre for Health Economics & Medicines Evaluation, Bangor University, Bangor, Wales.
Background: In the United Kingdom, it is estimated that 5,000 patients sustain eye injuries or ocular trauma requiring hospital admission annually, of which 250 patients will be permanently blinded. This study explores the cost-effectiveness of Adjunctive Steroid Combination in Ocular Trauma (ASCOT) given during surgery versus standard treatment in vitreoretinal surgery in patients with open globe trauma.
Methods: This economic evaluation was embedded alongside the ASCOT RCT (ClinicalTrials.
Cont Lens Anterior Eye
December 2024
Optometry and Vision Science Research Groups (OVSRG), School of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UK. Electronic address:
Antibiotic eyedrops typically require frequent instillation due to the eye's defensive mechanisms limiting drugs from reaching target sites. This may risk patient non-adherence and treatment inefficacy. The aim of this study was to develop a biocompatible and fully soluble ocular film insert to enhance the delivery of levofloxacin, as well as the handling procedure for its administration; based on the anatomical dimensions and physiological conditions of the human eye.
View Article and Find Full Text PDFJ Fr Ophtalmol
December 2024
Cornea and Refractive Surgery Department, Asociación para Evitar la Ceguera en México, I.A.P., Mexico City, Mexico.
Purpose: To evaluate the clinical outcomes of topical 5-fluorouracil (5-FU) 1% as first-line therapy for giant ocular surface squamous neoplasia (OSSN).
Materials And Methods: This was a non-comparative cohort study. We included patients with biopsy-proven giant OSSN in a tertiary-care setting.
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