AI Article Synopsis
- A new method for sulfonylation using gold catalysis has been developed, involving the reaction of aryl iodides with various sodium sulfinates.
- This process allows for the efficient creation of functionalized aryl sulfones by using different types of sodium sulfinates, including those with CF, CHF, CH, and alkyl groups.
- The gold-catalyzed sulfonylation provides a complementary synthetic route for producing aryl sulfones with electron-donating groups, expanding the options in organic chemistry.
Article Abstract
A gold-catalyzed sulfonylation reaction of aryl iodides with different sodium sulfinates facilitated by the ligand-enabled Au(I)/Au(III) redox catalysis was developed. In the reaction of gold-catalyzed C-S coupling, a variety of functionalized sodium sulfinates, such as CF, CHF, CH, and alkyl groups, can react smoothly with aryl iodides to directly construct diversely functionalized aryl sulfones. This gold-catalyzed sulfonylation offers a complementary method for synthesizing functionalized aryl sulfones with electron-donating groups.
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| http://dx.doi.org/10.1021/acs.orglett.4c03724 | DOI Listing |
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