AI Article Synopsis
- Monkeypox virus (MPXV) is causing a global outbreak, raising questions about different antibody responses from vaccination versus actual infection.
- A study found that convalescent individuals (those who recovered from MPXV) had higher neutralizing antibodies against the virus compared to vaccinated and non-infected people one month after exposure.
- Both groups experienced a significant decrease in antibody levels after eight months, indicating a need for improved vaccine strategies to ensure longer-lasting immunity and reduce breakthrough infections.
Article Abstract
Monkeypox virus (MPXV) has recently caused a global disease outbreak in humans. Differences in the neutralizing antibody response to vaccination vs. MPXV infection remain poorly understood. Here, we examined the neutralization of MPXV and VACV by sera from a cohort of convalescent and vaccinated individuals at 1- and 8-months post-exposure. Convalescent individuals displayed higher neutralizing antibody titers against MPXV than vaccinated and MPXV-naïve persons at one-month post-exposure. Neutralizing antibody titers had waned significantly in both groups at 8 months. This study suggests additional vaccine strategies are needed to elicit a durable humoral response and prevent breakthrough infections.
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Source |
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| http://dx.doi.org/10.1093/infdis/jiae515 | DOI Listing |
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