AI Article Synopsis
- Researchers using 1H-MRS to study brain metabolites often misinterpret correlations within the same area of the brain due to statistical non-independence.
- A recent article discusses how this issue affects biological interpretations but suggests the analysis might be lacking in depth.
- The authors, Hong et al., argue that normalizing with water instead of creatine avoids spurious correlations, but the text critiques this claim, stating that water-normalized values can still present significant false correlations.
Article Abstract
1H-MRS investigators studying brain metabolite concentrations often attribute biological significance to correlations between calculated metabolite values within the same voxel. A recent report in this journal provides a valuable perspective on how statistical non-independence of such values can undermine biological interpretations of their correlations. However, careful examination of this issue suggests their critical analysis does not go far enough. Hong et al. claim that appropriate water normalization, unlike creatine normalization, eliminates the problem of spurious correlation. Both logical and empirical considerations show this is not the case. Correlations between water-normalized metabolite values are also prone to substantial spurious correlations.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563549 | PMC |
| http://dx.doi.org/10.1177/0271678X241290018 | DOI Listing |
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