AI Article Synopsis
- This study analyzed the bone mineral density (BMD) changes in hospitalized COVID-19 patients to understand how the infection affects bone health over time.
- A retrospective analysis of 1767 patients identified three distinct BMD trajectories, showing varying levels of decline and significant links between these patterns and patient demographics like age and sex.
- The findings indicate that BMD trajectories are associated with clinical outcomes like mortality and hospital stay length, suggesting the need for better bone health management in COVID-19 patients.
Article Abstract
Background: In this study, we aimed to identify bone mineral density (BMD) trajectories of hospitalised patients with coronavirus disease 2019 (COVID-19) and to determine the prognostic role of the trajectory groups.
Methods: This is a retrospective study of hospitalised patients with COVID-19 treated in our hospital from November 2022 to February 2023. BMD was manually measured from the thoracic 12 (T12) and lumbar one (L1) vertebra using chest computed tomography images. We constructed group trajectory models using group-based trajectory modelling. We performed the logistic regression analysis to associate the BMD trajectory pattern with clinical outcomes.
Results: This study included 1767 patients. The mean follow-up time after discharge was 181.5 days (standard deviation (SD) = 9.7). There were 1137 (64.3%) male patients, and more than 80% of patients were aged >60 years. We successfully identified three latent BMD trajectories to reveal the dynamic effects of COVID-19 infection on bone health in patients, namely, the early low-normal decline group, the average, and the early high-rapid decline group. All groups demonstrated consistent overall declining trends. A significant association was observed between BMD trajectory pattern (T12 or L1) and baseline characteristics of sex, age, and penetrating keratoplasty (P < 0.05). Our study showed that the BMD trajectories were significantly associated with mortality. Furthermore, we found that these trajectories were also associated with the length of hospital stay.
Conclusions: This study provided evidence for the COVID-19 process to bone health, as well as evidence on strengthening bone health management before and after COVID-19 infection. BMD trajectories may help manage bone health and guide treatment in patients with COVID-19.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487469 | PMC |
| http://dx.doi.org/10.7189/jogh.14.05029 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
This article provides an overview of vitamin C for preventing and treating respiratory infections. Studies in a wide variety of animals have shown vitamin C to be protective against infections. In controlled trials in the general human population, >1 g/day vitamin C did not prevent common colds.
View Article and Find Full Text PDFThe coronavirus main protease (MPro) plays a pivotal role in viral replication and is the target of several antivirals against SARS-CoV-2. In some species, CRCs of MPro enzymatic activity can exhibit biphasic behavior in which low ligand concentrations activate the enzyme whereas higher ones inhibit it. While this behavior has been attributed to ligand-induced dimerization, quantitative enzyme kinetics models have not been fit to it.
View Article and Find Full Text PDFBehavioral and Health Outcomes of mRNA COVID-19 Vaccination: A Case-Control Study in Japanese Small and Medium-Sized Enterprises.
Cureus
December 2024
Health Data Science, Learning Health Society Institute, Nagoya, JPN.
Background Despite ongoing waves of Coronavirus disease 2019 (COVID-19) infections, including significant surges such as the 10th wave, understanding the impact of messenger RNA (mRNA) COVID-19 vaccination on infection risk and associated behavioral changes remains crucial. This study aims to urgently evaluate the effects of mRNA COVID-19 vaccination on COVID-19 infection rates and related behaviors among participants of the Yamato Project, which includes employees of Japanese small and medium-sized enterprises (SMEs). Methods A case-control study was conducted using data collected from a survey administered by the Japan Small and Medium Enterprise Management Council in December 2023.
View Article and Find Full Text PDFComparison of the Degree of Chest CT Scan Abnormalities in COVID-19 and Influenza Patients.
Cureus
December 2024
Radiology, Michigan State University, East Lansing, USA.
Introduction In the emergency department (ED), COVID-19 and influenza are two common viral diseases. They cause similar symptoms in the respiratory system, and most patients' symptoms are relatively mild. We have reported previously that COVID-19 and influenza infections cause similar abnormalities in chest X-ray readings in the ED.
View Article and Find Full Text PDFAssessing favipiravir impact on SARS-CoV-2 transmission within households: Insights from a multi-center study (FaviPrev).
J Virus Erad
December 2024
Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand.
Background: While certain studies have demonstrated that antiviral treatment administered to index patients with influenza can mitigate the transmission within households, the efficacy of anti-SARS-CoV-2 agents in curtailing household transmission remains to be conclusively established.
Methods: A retrospective study conducted from April 2021 to May 2022 across multiple centers in Thailand compared 892 individuals treated with favipiravir to 84 who received standard treatment among mild to moderate COVID-19 index patients. The study focused on the impact of favipiravir treatment in reducing household SARS-CoV-2 transmission by examining the secondary attack rate.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!