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| http://dx.doi.org/10.3389/fncom.2024.1455530 | DOI Listing |
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Antibody responses in Burkinabe children against proteins associated with reduced risk of clinical malaria.
Front Immunol
March 2025
Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan.
Individuals residing in malaria-endemic regions with high disease transmission can develop semi-immunity within five years of age. Although understanding the target of the IgGs in this age group helps discover novel blood-stage vaccine candidates and serological markers, it has not been well elucidated due to limited accessibility to plasmodial antigens and samples. This study presents the first comprehensive analysis of antibody levels in plasma obtained from Burkinabe children (n=80, aged 0 to 5 years) to 1307 proteins expressed by the eukaryotic wheat germ cell-free system.
View Article and Find Full Text PDFKAN-EEG: towards replacing backbone-MLP for an effective seizure detection system.
R Soc Open Sci
March 2025
School of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Sydney, NSW 2006, Australia.
The landscape of artificial intelligence (AI) research is witnessing a transformative shift with the emergence of the Kolmogorov-Arnold network (KAN), presenting a novel architectural paradigm aimed to redefine the structural foundations of AI models, which are based on multilayer perceptron (MLP). Through rigorous experimentation and evaluation, we introduce the KAN-electroencephalogram (EEG) model, a tailored design for efficient seizure detection. Our proposed network is tested and successfully generalized on three different datasets, one from the USA, one from Europe, and one from Oceania, recorded with different front-end hardware.
View Article and Find Full Text PDFHe Who Wills the End Wills the Means: An Overview of Trusts for Physicians.
J Clin Aesthet Dermatol
February 2025
Dr. Galambus is with the University of North Texas in Dallas, Texas.
Even though physicians often have the access and ability to generate significant wealth, many report poor financial literacy and education. They may not fully understand the options available to them for passing on their wealth to their next of kin. Options include wills, trusts, or, if one dies without a will, simply following the states intestate succession laws.
View Article and Find Full Text PDFA global survey about undiagnosed rare diseases: perspectives, challenges, and solutions.
Front Public Health
March 2025
National Center Rare Diseases - Undiagnosed Rare Diseases Interdepartmental Unit, Istituto Superiore di Sanità, Rome, Italy.
Background: Undiagnosed rare diseases (URDs) are a complex and multifaceted challenge, especially in low-and medium-income countries. They affect individuals with unique clinical features and lack a clear diagnostic label. Although the Undiagnosed Diseases Network International (UDNI) definition of URDs is not universally accepted, it is widely recognized.
View Article and Find Full Text PDFAim: In Japan, emergency ambulance dispatches involve minor cases requiring outpatient services, emphasizing the need for improved public guidance regarding emergency care. This study evaluated both the medical plausibility of the GPT model in aiding laypersons to determine the need for emergency medical care and the laypersons' interpretations of its outputs.
Methods: This cross-sectional study was conducted from December 10, 2023, to March 7, 2024.
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