AI Article Synopsis
- The study investigates the relationship between serum albumin (SA) levels and the risk of early postoperative infections in patients undergoing total knee arthroplasty (TKA), particularly focusing on those with hypoalbuminemia (SA < 3.5 g/dL).
- Data from 490 TKAs were analyzed, and while five patients experienced early infections needing surgery, there were no significant differences in SA levels or related parameters between the infected and non-infected groups.
- The findings indicate that patients who developed infections had a higher reduction in SA levels around the time of their surgery but no clear link was established between SA levels and the occurrence of infections, suggesting further research is needed on the SA threshold of 3
Article Abstract
Purpose: Patients with hypoalbuminemia, (serum albumin (SA) < 3.5 g/dL) are at greater risk for complications after surgery, including increased postoperative infection rates after total knee arthroplasty (TKA). This study aimed to analyze both preoperative and postoperative SA in patients who experienced acute periprosthetic infection within the first 4 weeks after surgery.
Methods: We retrospectively analyzed data from 490 consecutive TKAs (314 patients). Five patients developed early acute infection requiring surgical treatment. SA data were collected preoperatively (SA) and 1 week postoperatively (SA) to evaluate SA dynamics. Multiple patient and operative parameters that could influence SA were also analyzed.
Results: No statistical differences were found in parameters expected to influence SA values between the surgically treated (STG) and non-treated groups (non-STG). None of the patients in STG had SA and SA below 3.5 g/dL. However, the amount and rate of SA reduction before and after surgery were significantly greater in STG than in non-STG.
Conclusion: SA dynamics revealed a greater reduction in both the amount and rate in STG before and after surgery than in non-STG. No correlation was found between early acute periprosthetic infection after TKA and each SA and SA time point. Further evaluation of the SA value of 3.5 g/dL as a threshold for acute early acute infection is warranted.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488267 | PMC |
| http://dx.doi.org/10.1186/s13018-024-05166-0 | DOI Listing |
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