AI Article Synopsis
- Coronary artery atherosclerosis and calcification are key factors in developing coronary artery disease, and coronary artery calcium scoring (CACS) helps assess risk levels for patients.
- A study with 435 patients with stable ischemic heart disease categorized them based on CACS and monitored them for major cardiovascular events over two years.
- Results indicated that patients with a high CACS (≥400) experienced significantly more major adverse cardiovascular events, with age, risk score, and other factors being independent predictors of these outcomes.
Article Abstract
Background: Coronary artery atherosclerosis and calcification are the precursors to the development of coronary artery disease and its complications. Coronary artery calcium scoring (CACS) is useful as a risk-stratification tool in coronary artery disease.
Objective: The current study was designed to identify the relationship between CACS and major adverse cardiovascular outcomes in patients with stable coronary artery disease.
Methods: The study was conducted on 435 patients with stable ischemic heart disease. The patients were classified into two groups according to their coronary artery calcium score (CACS): group I (n = 220 patients), whose calcium score was mild to moderate (< 400), and group II (n = 215 patients), whose calcium score was high (≥ 400). All patients were closely monitored for two years to assess major adverse cardiovascular events (MACE).
Results: After 2 years of follow-up, MACE drastically increased in Group II in the form of unstable angina, myocardial infarction, demand for percutaneous coronary intervention, and heart failure. Multivariate regression analysis showed that age ≥ 55 years, Framingham risk score > 10, CACS ≥ 400, body mass index ≥ 30 kg/m2, and the proximal lesions of the vessels were the independent risk factors for major cardiac events.
Conclusion: The coronary calcium score is a distinct feature of coronary atherosclerosis, and a score of 400 or higher is a reliable, noninvasive predictor of the progression of coronary artery diseases and their consequences, including MACE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484115 | PMC |
| http://dx.doi.org/10.1186/s12872-024-04157-7 | DOI Listing |
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