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[Selective assessment of biomechanical properties of the lens capsule].
Vestn Oftalmol
December 2024
Institute of Regenerative Medicine of the Sechenov University, Moscow, Russia.
Unlabelled: The scientific and practical interest in studying the biomechanical characteristics of the lens capsule, on the one hand, is associated with its anatomical significance in modern microinvasive phaco surgery, and on the other hand, with investigation of the mechanisms of lens curvature changes during accommodation. Selective study of the biomechanical properties of the lens capsule aims to identify characteristics of various regions and surfaces of the capsule.
Purpose: This study is a comparative analysis of age-related changes in the biomechanical properties of the anterior (AC) and posterior (PC) lens capsules in humans.
Serial Dependence in Smooth Pursuit Eye Movements of Preadolescent Children and Adults.
Invest Ophthalmol Vis Sci
December 2024
School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
Purpose: Serial dependence refers to the attraction of current perceptual responses toward previously seen stimuli. Despite extensive research on serial dependence, fundamental questions, such as how serial dependence changes with development, whether it affects the perception of sensory input, and what qualifies as serial dependence, remain unresolved. The current study aims to address these questions.
View Article and Find Full Text PDFPathology Findings and In-Life Correlates in the Nonclinical Development of Adeno-Associated Virus (AAV)-Based Retinal Gene Therapies.
Toxicol Pathol
December 2024
GEMpath, Inc., Longmont, Colorado, USA.
Adeno-associated virus (AAV)-based vectors are the most frequently used platform for retinal gene therapy. Initially explored for the treatment of loss-of-function mutations underpinning many inherited retinal diseases, AAV-based ocular gene therapies are increasingly used to transduce endogenous cells to produce therapeutic proteins, thus producing site-specific biofactories. Relatively invasive ocular routes of administration (ROA) mean prominent procedure-related in-life, and histopathological findings may be observed with some regularity.
View Article and Find Full Text PDFU-shaped association between residential greenness and keratoconus.
Environ Res
December 2024
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. Electronic address:
Keratoconus is a blinding corneal disorder influenced by genetic factors. Whether environmental factors influence it remains unclear. Here, we observed a U-shaped association between residential greenness and keratoconus, with increased odds ratios (ORs) at low and high greenness levels.
View Article and Find Full Text PDFEarly exposure to Western Diet exacerbates visual outcomes in female mice.
bioRxiv
December 2024
Laboratory of Neurovascular Control of Homeostasis, Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
Obesity, a growing pandemic in Western societies, significantly impacts metabolic health and contributes to visual disorders. While the systemic consequences of obesity, such as chronic inflammation and insulin resistance, are well-studied in adults, its early-life effects on retinal health remain underexplored. Using a maternal Western Diet (WD) exposure model, we investigated the developmental impact of early-life metabolic disturbances on retinal and cognitive function.
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