Anything you can do, glycans do better: deglycosylation and noncanonical ubiquitination vie to rule the proteasome.

Trends Biochem Sci

Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. Electronic address:

Published: December 2024

The Nrf1/Nfe2L1 transcription factor is a master regulator of proteasome biogenesis. New work by Yoshida and colleagues reveals a surprising mechanism by which ubiquitination of N-glycosylated Nrf1 controls its function.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624994PMC
http://dx.doi.org/10.1016/j.tibs.2024.10.001DOI Listing

Publication Analysis

Top Keywords

glycans better
4
better deglycosylation
4
deglycosylation noncanonical
4
noncanonical ubiquitination
4
ubiquitination vie
4
vie rule
4
rule proteasome
4
proteasome nrf1/nfe2l1
4
nrf1/nfe2l1 transcription
4
transcription factor
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!