AI Article Synopsis
- High endothelial venules (HEVs) are specialized blood vessels that help lymphocytes move from blood into tissues, and this study is the first to investigate their presence in pleural tissue associated with tumors.
- The researchers analyzed 149 surgical pleural biopsies, using immunohistochemistry to identify HEVs, finding them in 68% of the samples, with a higher occurrence in neoplastic diseases compared to non-neoplastic ones.
- The findings suggest that HEVs play a role in the immune response within pleural diseases, highlighting their significance in both inflammatory and cancer-related conditions in the pleural cavity.*
Article Abstract
Introduction: High endothelial venules (HEVs) are vessels specialized in the extravasation of lymphocytes from the blood to the tissue implicated in the immune microenvironment of several tumors. Their presence has been never studied in the pleural tissue.
Material And Methods: We retrospectively studied 149 surgical pleural biopsies by immunohistochemistry for MECA-79 expression, a marker specifically recognizing HEVs. The tissues included 44 (44 %) inflammatory and 105 (56 %) neoplastic diseases. The latter corresponded to 34 (22.8 %) mesotheliomas and 71 (47.7 %) metastases from lung (n=50) or breast (n=21) primaries.
Results: HEVs were present in 102 (68 %) of all pleural specimens with a mean number of foci containing HEVs of 13.33 (±20.64). Neoplastic pleural pathologies harbored HEVs in 73.3 % of the cases compared to the non-neoplastic pathologies which harbored HEVs in 56.8 % of the cases (p=0.048). Their presence did not differ between pulmonary or mammary metastasis (p=0.7).
Conclusion: We show for the first time that HEVs are present in the pleural cavity probably participating in the immune microenvironment of inflammatory and neoplastic pleural disease.
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| http://dx.doi.org/10.1016/j.prp.2024.155661 | DOI Listing |
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