Traditional methods of the α-oxidation of amides often require preactivation or umpolung of amides. In this study, we introduce a general electrochemical approach for the direct α-C()-H alkoxylation of thiophene-containing amides. This mild and selective electrochemical method provides a modular and alternative efficient route to the highly valuable α-oxygenated thiophene-containing amide scaffolds.
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| http://dx.doi.org/10.1021/acs.joc.4c01632 | DOI Listing |
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