Acridine-based hybrid fluorescent dyes represent a category of dyes that integrate the acridine chromophore with other functional groups or materials to enhance their fluorescence properties. These dyes have garnered substantial attention across various domains, encompassing bioimaging, sensing, and optoelectronics. In recent years, researchers have directed their efforts toward fabricating acridine-based hybrid fluorescent dyes with improved water solubility, biocompatibility, and targeting capabilities. These advancements have facilitated their utilization in biological imaging applications, such as monitoring cellular processes, investigating protein-protein interactions, and detecting specific biomolecules. This review delineates the recent progress in synthesizing acridine-based hybrid fluorescent dyes and their applications in optical properties over the past decade. This review is anticipated to catalyze the development of innovative fluorescent materials featuring heightened properties and functionalities.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10895-024-04001-3DOI Listing

Publication Analysis

Top Keywords

acridine-based hybrid
16
hybrid fluorescent
16
fluorescent dyes
16
dyes
6
fluorescent
5
advances synthesis
4
synthesis optical
4
optical applications
4
acridine-based
4
applications acridine-based
4

Similar Publications

Acridine-based hybrid fluorescent dyes represent a category of dyes that integrate the acridine chromophore with other functional groups or materials to enhance their fluorescence properties. These dyes have garnered substantial attention across various domains, encompassing bioimaging, sensing, and optoelectronics. In recent years, researchers have directed their efforts toward fabricating acridine-based hybrid fluorescent dyes with improved water solubility, biocompatibility, and targeting capabilities.

View Article and Find Full Text PDF

Design and Development of Triazole Derivatives as Prospective Anticancer Agents: A Review.

Anticancer Agents Med Chem

October 2022

Department of Chemistry, Kanoria P.G. Mahila Mahavidyalaya, Jaipur 302004, Rajasthan, India.

Background: In recent years, there has been a crucial need for the design and development of novel anticancer drugs that can lessen the serious health problems and unwanted side effects associated with currently used anticancer drugs. The triazole nucleus is well-recognized to possess numerous pharmacological activities, including anticancer, as revealed by various investigations on anticancer drugs and the latest research findings.

Objective: The aim of this review article is to summarise the anticancer potential of 1, 2, 3-triazole, 1, 2, 4-triazole and heterocycle-fused triazole derivatives against several human cancer cell lines, compiling research articles published between 2010 and 2021.

View Article and Find Full Text PDF

Acridine-Based Antimalarials-From the Very First Synthetic Antimalarial to Recent Developments.

Molecules

January 2021

LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, R. do Campo Alegre, 4169-007 Porto, Portugal.

Malaria is among the deadliest infectious diseases in the world caused by parasites. Due to the high complexity of the parasite's life cycle, we partly depend on antimalarial drugs to fight this disease. However, the emergence of resistance, mainly by , has dethroned most of the antimalarials developed to date.

View Article and Find Full Text PDF

'Acridines' as New Horizons in Antifungal Treatment.

Molecules

March 2020

Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland.

Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited.

View Article and Find Full Text PDF

Platinum-acridine hybrid agents show low-nanomolar potency in chemoresistant non-small cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous genotoxicity of these agents and improve their pharmacological properties, a modular build-click-screen approach was used to evaluate a small library of twenty hybrid agents containing truncated and extended chromophores of varying basicities. Selected derivatives were resynthesized and tested in five NSCLC cell lines representing large cell, squamous cell, and adenocarcinomas.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!