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Transfer RNA Levels Are Tuned to Support Differentiation During Drosophila Neurogenesis.
Genes (Basel)
December 2024
Quantitative and Systems Biology Graduate Program, Department of Molecular and Cell Biology, University of California, Merced, CA 95343, USA.
Background/objectives: Neural differentiation requires a multifaceted program to alter gene expression along the proliferation to the differentiation axis. While critical changes occur at the level of transcription, post-transcriptional mechanisms allow fine-tuning of protein output. We investigated the role of tRNAs in regulating gene expression during neural differentiation in larval brains.
View Article and Find Full Text PDFThe RNA-binding protein Modulo promotes neural stem cell maintenance in Drosophila.
PLoS One
December 2024
Department of Biology, University of New Mexico, Albuquerque, New Mexico, United States of America.
A small population of stem cells in the developing Drosophila central nervous system generates the large number of different cell types that make up the adult brain. To achieve this, these neural stem cells (neuroblasts, NBs) divide asymmetrically to produce non-identical daughter cells. The balance between stem cell self-renewal and neural differentiation is regulated by various cellular machinery, including transcription factors, chromatin remodelers, and RNA-binding proteins.
View Article and Find Full Text PDFNeuronal Progenitors Suffer Genotoxic Stress in the Clock Mutant .
Cells
November 2024
Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, 00185 Rome, Italy.
The physiological role and the molecular architecture of the circadian clock in fully developed organisms are well established. Yet, we have a limited understanding of the function of the clock during ontogenesis. We have used a null mutant () of the clock gene () in to ask whether PER may play a role during normal brain development.
View Article and Find Full Text PDFPredicting modular functions and neural coding of behavior from a synaptic wiring diagram.
Nat Neurosci
December 2024
Institute for Computational Biomedicine and the Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.
A long-standing goal in neuroscience is to understand how a circuit's form influences its function. Here, we reconstruct and analyze a synaptic wiring diagram of the larval zebrafish brainstem to predict key functional properties and validate them through comparison with physiological data. We identify modules of strongly connected neurons that turn out to be specialized for different behavioral functions, the control of eye and body movements.
View Article and Find Full Text PDFEvolutionarily conserved brainstem architecture enables gravity-guided vertical navigation.
PLoS Biol
November 2024
Departments of Otolaryngology, Neuroscience & Physiology, and the Neuroscience Institute, New York University Grossman School of Medicine, New York, New York, United States of America.
The sensation of gravity anchors our perception of the environment and is important for navigation. However, the neural circuits that transform gravity into commands for navigation are undefined. We first determined that larval zebrafish (Danio rerio) navigate vertically by maintaining a consistent heading across a series of upward climb or downward dive bouts.
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