Roles of microRNA-486-5p in the diagnosis and the association with clinical symptoms of cervical cancer.

To explore the predictive value of in early cervical cancer and the associations of with different clinical symptoms. A total of 185 women were recruited. The relative expression levels of serum were analyzed by real-time polymerase chain reaction. The receiver operator characteristic curves were utilized to reflect the predictive performance of and squamous cell carcinoma antigen for early cervical cancer. Univariate logistic regression and ranked logistic regression were used to explore the associations of with different clinical symptoms of early cervical cancer, with odd ratios (ORs) and 95% confidence intervals. Eighty-one women (44.26%) had early cervical cancer. The relative expression of serum was 1.99-fold higher in early cervical cancer patients than that in controls ( < 0.0001). The predictive performance of for early cervical cancer was significantly superior to that of squamous cell carcinoma antigen, with an area under the curve of 0.865 ( < 0.001), sensitivity of 1.000 and specificity of 0.804. In addition, overexpressed was associated with high odds of maximum tumor diameter increase (OR = 1.30, 95% CI: [1.01-1.66]). may be a potential biomarker for the early cervical cancer diagnosis, and was linked to the risk of maximum tumor diameter.