AI Article Synopsis
- DRESS is a severe skin reaction that includes symptoms like skin rash, fever, and organ involvement, while TEN is an even more severe condition causing skin necrosis and detachment.
- Hemophagocytic lymphohistiocytosis (HLH) is an extreme immune response linked to severe skin reactions like DRESS.
- A case is presented where a severe DRESS reaction occurred from allopurinol use and overlapped with TEN, possibly triggered by vancomycin for sepsis, ultimately leading to a fatal HLH situation.
Article Abstract
Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse reaction (SCAR) characterized by an extensive skin rash associated with visceral organ involvement, fever, eosinophilia, atypical lymphocytosis, and lymphadenopathy. Toxic epidermal necrolysis (TEN) is a more severe, distinct adverse cutaneous reaction that causes extensive necrosis and detachment of the epidermis, involving over 30% of the body surface area (BSA). Hemophagocytic lymphohistiocytosis (HLH), a form of excessive immune activation, is known to be associated with SCARs such as DRESS. We present a peculiar case of overlap between different SCARs to reiterate their gravity, a severe form of DRESS triggered by the use of allopurinol overlapping with the aggressive TEN possibly from interaction with vancomycin administered for severe sepsis, which was complicated by a fatal case of HLH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480927 | PMC |
| http://dx.doi.org/10.7759/cureus.69503 | DOI Listing |
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