A small bowel obstruction (SBO) involves partial or complete blockage of the small intestine. Complete high-grade or closed-loop obstructions constitute acute surgical emergencies necessitating urgent intervention to prevent severe complications. Several probable etiologies of SBO have been identified, including malignancy, stool impaction, and inflammatory bowel disease; however, post-surgical adhesion is the most prevalent cause in the developed world. A SBO can be diagnosed clinically after a physical examination, but imaging is needed for surgical assessment and management. Misdiagnosis and inadequate management of SBO can cause several complications, such as intestinal necrosis and perforation. Therefore, when required, rapid diagnosis and surgical intervention are critical to avoiding mortality. Computer tomography (CT) and small bowel follow-through (SBFT) are widely utilized imaging modalities for confirmatory diagnosis of SBO. This case series features three patients who had exploratory laparotomies following extensive clinical evaluations and a radiologically confirmed diagnosis of SBO. All three cases involved numerous surgeries. The patients presented with severe abdominal discomfort and received surgical intervention after a CT scan confirmed the diagnosis and conservative therapy failed. In this case, all patients had different presentations but responded adequately to the same treatment modalities with no postoperative complications.
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http://dx.doi.org/10.7759/cureus.69487 | DOI Listing |
Rheumatol Ther
January 2025
LBAI, UMR1227, Univ Brest, Inserm, Brest, France.
Introduction: Celiac disease (CD) affects the small intestine, leading to a progressive disappearance of intestinal villi, and can be found in association with several other autoimmune and inflammatory conditions. The main objective of this study was to determine the prevalence and the clinical significance of anti-transglutaminase and anti-endomysium antibodies in patients diagnosed with early rheumatoid arthritis (RA) and spondyloarthritis (SpA).
Methods: We measured anti-transglutaminase and anti-endomysium antibodies in biobanked serum samples at inclusion in two French prospective multicenter cohorts of patients with suspected early rheumatoid arthritis (ESPOIR, n = 713) and spondyloarthritis (DESIR, n = 709).
Adv Sci (Weinh)
January 2025
Department for Functional Materials in Medicine and Dentistry, University Hospital Würzburg, Würzburg, Germany.
Studying the molecular basis of intestinal infections caused by enteric pathogens at the tissue level is challenging, because most human intestinal infection models have limitations, and results obtained from animals may not reflect the human situation. Infections with Salmonella enterica serovar Typhimurium (STm) have different outcomes between organisms. 3D tissue modeling of primary human material provides alternatives to animal experimentation, but epithelial co-culture with immune cells remains difficult.
View Article and Find Full Text PDFVet Res Forum
November 2024
Department of Animal Science, Faculty of Agriculture, Ahi Evran University, Kırşehir, Türkiye.
Japanese quail () is a popular experimental animal model in scientific research. The present study investigated the effects of dietary multiple enzyme supplementation on growth performance, carcass characteristics, nutrient digestibility and small intestinal histomorphology in quails fed diets based on wheat and soya bean meal. A total number of 192 1-day-old quails were assigned to three treatments with 16 replicates in each and four quails replicate for 38 days.
View Article and Find Full Text PDFPrev Med Rep
January 2025
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Objective: The noncompliance rate with routine or surveillance colonoscopies is high, and the underlying reasons remain unverified among Asian patients with inflammatory bowel disease (IBD). This study aimed to examine the perceptions of Asian patients with IBD regarding bowel preparation and colonoscopy and their attitudes toward the recommended intervals for colonoscopies.
Methods: Using data from one medical center between July 2020 and May 2022, we analyzed the perceptions of bowel preparation and colonoscopy and attitudes toward examination intervals among 94 patients with IBD (Crohn's disease, 41; ulcerative colitis, 53).
Inflamm Bowel Dis
January 2025
Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Midorigaoka-Higashi 2-1-1-1, Asahikawa Hokkaido, 078-8510, Japan.
Background: Crohn's disease (CD) is a refractory inflammatory bowel disease with an unclear etiology. CircularRNA (circRNA) has been highlighted as a novel class of functional noncoding RNAs associated with the pathogenesis of various diseases. However, the functions of circRNA in CD remain unclear.
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